지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
- 수록면
- 581 - 593 (13page)
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초록· 키워드
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Toxoplasmosis is an opportunistic infection caused by the protozoan parasite Toxoplasma gondii. T. gondii is widespread globally and causes severe diseases in individuals with impaired immune defences as well as congenitally infected infants. The high prevalence rate in some parts of the world such as South America and Africa, coupled with the current drug treatments that trigger hypersensitivity reactions, makes the development of immunotherapeutics intervention a highly important research priority. Immunotherapeutics strategies could either be a vaccine which would confer a pre-emptive immunity to infection, or passive immunization in cases of disease recrudescence or recurrent clinical diseases. As the severity of clinical manifestations is often greater in developing nations, the development of well-tolerated and safe immunotherapeutics becomes not only a scientific pursuit, but a humanitarian enterprise. In the last few years, much progress has been made in vaccine research with new antigens, novel adjuvants, and innovative vaccine delivery such as nanoparticles and antigen encapsulations. A literature search over the past 5 years showed that most experimental studies were focused on DNA vaccination at 52%, followed by protein vaccination which formed 36% of the studies, live attenuated vaccinations at 9%, and heterologous vaccination at 3%; while there were few on passive immunization. Recent progress in studies on vaccination, passive immunization, as well as insights gained from these immunotherapeutics is highlighted in this review.
목차
Abstract
INTRODUCTION
VACCINES
PROTEIN VACCINES
DNA VACCINES
LIVE, ATTENUATED VECTORS
PASSIVE IMMUNIZATION
CONCLUDING REMARKS
REFERENCES
참고문헌 (91)
참고문헌 신청
Chowdhury M / 1986 / Toxoplasmosis : a review / J Med 17:373~396
Brindle R / 1991 / Toxoplasma antibodies in HIV-positive patients from Nairobi / Trans R Soc Trop Med Hyg 85:750~751
Mui EJ / 2008 / Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo / PLoS Negl Trop Dis 2:190
Khan A / 2006 / Genetic Divergence of Toxoplasma gondii Strains Associated with Ocular Toxoplasmosis, Brazil / Emerg Infect Dis 12:942~949
Bottos J / 2009 / Bilateral retinochoroiditis caused by an atypical strain of Toxoplasma gondii / Br J Ophthalmol 93:1546~1550
Brindle R / 1991 / Toxoplasma antibodies in HIV-positive patients from Nairobi / Trans R Soc Trop Med Hyg 85:750~751
Mui EJ / 2008 / Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo / PLoS Negl Trop Dis 2:190
Khan A / 2006 / Genetic Divergence of Toxoplasma gondii Strains Associated with Ocular Toxoplasmosis, Brazil / Emerg Infect Dis 12:942~949
Bottos J / 2009 / Bilateral retinochoroiditis caused by an atypical strain of Toxoplasma gondii / Br J Ophthalmol 93:1546~1550
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UCI(KEPA) : I410-ECN-0101-2016-513-001291957