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자료유형
학술저널
저자정보
Mi Ja Chung (Kangwon National University) Jeong-Mi Kim (Kangwon National University) Sangchul Lee (Corporate-affiliated Research Institute of Academic-Industrial-Institutional Cooperation) Taewoo Kim (Kangwon National University) Daejung Kim (Kangwon National University) Jongmi Baek (Kangwon National University) Taehyuk Kim (Kangwon National University) Jaesung Lee (Kangwon National University) Kyoungkon Kim (Kangwon National University) Jin A Yoon (Baewha Women’s University) Myeon Choe (Kangwon National University)
저널정보
대한지역사회영양학회 Nutrition Research and Practice Nutrition Research and Practice Vol.6 No.2
발행연도
2012.4
수록면
97 - 105 (9page)

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Schizandra chinensis Baillon is a traditional folk medicine plant that is used to treat and prevent several inflammatory diseases and cancer in Korea, but the underlying mechanisms involved in its anti-allergic activity are not fully understood. This study was designed to investigate mechanisms of anti-allergic activity of a Schizandra chinensis Baillon water extract (SCWE) in immunoglobulin E (IgE)-antigen complex-stimulated RBL2H3 cells and to assess whether gastric and intestinal digestion affects the anti-allergic properties of SCWE. Oxidative stress is an important consequence of the allergic inflammatory response. The antioxidant activities of SCWE increased in a concentration-dependent manner. RBL-2H3 cells were sensitized with monoclonal anti-dinitrophenol (DNP) specific IgE, treated with SCWE, and challenged with the antigen DNP-human serum albumin. SCWE inhibited β-hexosaminidase release and expression of interleukin (IL)-4, IL-13, and tumor necrosis factor-alpha (TNF-α) mRNA and protein in IgE-antigen complex-stimulated RBL2H3 cells. We found that digested SCWE fully maintained its antioxidant activity and anti-allergic activity against the IgE-antigen complex-induced activation of RBL-2H3 cells. SCWE may be useful for preventing allergic diseases, such as asthma. Thus, SCWE could be used as a natural functional ingredient for allergic diseases in the food and/or pharmaceutical industries.

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Abstract
Introduction
Materials and Methods
Results
Discussion
References

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