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논문 기본 정보

자료유형
학술저널
저자정보
Yang Hee Kim (제주대학교) Young In Moon (제주농업기술센터) Young Hee Kang (한림대학교) Jung Sook Kang (제주대학교)
저널정보
대한지역사회영양학회 Nutrition Research and Practice Nutrition Research and Practice Vol.1 No.4
발행연도
2007.12
수록면
298 - 304 (7page)

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This study was conducted to investigate the hypocholesterolemic effect of simvastatin (30 ㎎/㎏ BW) and antioxidant effect of coenzyme Q10 (CoQ10, 15 ㎎/㎏ BW) or green tea (5%) on erythrocyte Na leak, platelet aggregation and TBARS production in hypercholesterolemic rats treated with statin. Food efficiency ratio (FER, ADG/ADFI) was decreased in statin group and increased in green tea group, and the difference between these two groups was significant (p＜0.05). Plasma total cholesterol was somewhat increased in all groups with statin compared with control. Plasma triglyceride was decreased in statin group and increased in groups of CoQ10 and green tea, and the difference between groups of statin and green tea was significant (p＜0.05). Liver total cholesterol was not different between the control and statin group, but was significantly decreased in the group with green tea compared with other groups (p＜0.05). Liver triglyceride was decreased in groups of statin and green tea compared with the control, and the difference between groups of the control and green tea was significant (p＜0.05). Platelet aggregation of both the initial slope and the maximum was not significantly different, but the group with green tea tended to be higher in initial slope and lower in the maximum. Intracellular Na of group with green tea was significantly higher than the control or statin group (p＜0.05). Na leak in intact cells was significantly decreased in the statin group compared with the control (p＜0.05). Na leak in AAPH treated cells was also significantly reduced in the statin group compared with groups of the control and CoQ10 (p＜0.05). TBARS production in platelet rich plasma was significantly decreased in the groups with CoQ10 and green tea compared with the control and statin groups (p＜0.05). TBARS of liver was significantly decreased in the group with green tea compared with the statin group (p＜0.05). In the present study, even a high dose of statin did not show a cholesterol lowering effect, therefore depletion of CoQ10 following statin treatment in rats is not clear. More clinical studies are needed for therapeutic use of CoQ10 as an antioxidant in prevention of degenerative diseases independent of statin therapy.
#Simvastatin #CoQ10 #cholesterol #erythrocyte Na leak #platelet aggregation #TBARS production

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Abstract
Introduction
Materials and Methods
Results
Discussion
Literature cited

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