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논문 기본 정보

자료유형
학술저널
저자정보
Ji-Yeon Hwang (인제대학교) Jian Zhang (인제대학교) Min-Jung Kang (인제대학교) Soo-Kyung Lee (인제대학교) Hyun-A Kim (아미코젠) Jong-Jin Kim (아미코젠) Jung-In Kim (인제대학교)
저널정보
대한지역사회영양학회 Nutrition Research and Practice Nutrition Research and Practice Vol.1 No.2
발행연도
2007.6
수록면
100 - 104 (5page)

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Saururus chinensis Baill was reported to inhibit α-glucosidase in vitro and flatten postprandial increase in blood glucose in streptozotocin (STZ)-induced diabetic rats. We studied the effect of chronic consumption of S. chinensis Baill on blood glucose and lipid profile in STZ-induced diabetic male rats fed high fat diet. Male rats weighing 100-120 g were fed 30% fat diet with and without 10% freeze-dried leaves of S. chinensis Baill for 7 weeks after 1 week of adaptation. The rats were rendered diabetic by intravenous injection of STZ (60 ㎎/㎏) after 6-week feeding of the assigned diets. At 1 week after the injection, the rats were sacrificed after an overnight fast. Plasma glucose (380.2 ± 14.4 ㎎/dL), total cholesterol (93.9 ± 7.9 ㎎/dL) and triglyceride levels (123.6 ± 7.5 ㎎/dL) of the S. chinensis Baill group were significantly lower than those of the control group (418.1 ± 12.0 ㎎/dL, 119.9 ± 9.4 ㎎/dL, 152.0 ± 10.3 ㎎/dL, respectively, p<0.05). Chronic consumption of S. chinesis Baill significantly decreased maltase activity of the small intestinal mucosa (120.1 ± 8.7 U/g protein) compared with the control group (96.8 ± 7.0 U/g protein, p<0.05). These results suggest that S. chinensis Baill have hypoglycemic and hypolipidemic effects by inhibiting α-glucosidase activity in the animal model of diabetes mellitus.

목차

Abstract
Introduction
Materials and Methods
Results
Discussion
Literature Cited

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