지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.88 No.1
- 발행연도
- 2014.12
- 수록면
- 15 - 20 (6page)
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초록· 키워드
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Purpose: Downstaging after chemoradiotherapy (CRT) for rectal cancer usually occurs. The present study aimed to evaluate pathologic y-stage (yp-stage) and its influence on local recurrence and systemic recurrence in rectal cancer patients treated with CRT followed by surgical resection.
Methods: We retrospectively analyzed 261 patients underwent preoperative CRT and radical resection for rectal cancer between August 2004 and December 2010. Patients received preoperative CRT consisting of 5-fluorouracil and leucovorin delivered with concurrent pelvic radiation of 45.0?50.4 ㏉, followed by radical surgery at 6?8 weeks after CRT.
Results: Of the 261 patients, 24 (9.2%) had yp-stage 0, 83 (31.8%) had yp-stage I, 86 (32.9%) had yp-stage II, and 68 (26.1%) had yp-stage Ⅲ. Patients with yp-stage Ⅲ had a greater prevalence of preoperative CEA, poorly differentiated tumor, lymphovascular invasion (LVI) and perineural invasion (PNI) than patients with lower yp-stages. We found that yp-stage, preoperative CEA, LVI, PNI and tumor regression grade were significant prognostic factors for both local and systemic recurrence. In multivariate analysis, yp-stage, LVI and PNI were significant factors for local and systemic recurrence. During the median follow-up of 37.5 months, the five-year local recurrence-free survival rate was 100.0%, 95.0%, 89.3%, and 80.6% of yp-stage 0?Ⅲ, respectively. The five-year systemic recurrence-free survival was 95.8%, 75.3%, 71.4%, and 48.8% of yp-stages 0?Ⅲ, respectively.
Conclusion: The yp-stage after preoperative CRT for rectal cancer is closely correlated with local and systemic recurrencefree survival. Therefore, yp-stage should be considered as a prognostic factor for rectal cancer patients having a course of preoperative CRT.
Methods: We retrospectively analyzed 261 patients underwent preoperative CRT and radical resection for rectal cancer between August 2004 and December 2010. Patients received preoperative CRT consisting of 5-fluorouracil and leucovorin delivered with concurrent pelvic radiation of 45.0?50.4 ㏉, followed by radical surgery at 6?8 weeks after CRT.
Results: Of the 261 patients, 24 (9.2%) had yp-stage 0, 83 (31.8%) had yp-stage I, 86 (32.9%) had yp-stage II, and 68 (26.1%) had yp-stage Ⅲ. Patients with yp-stage Ⅲ had a greater prevalence of preoperative CEA, poorly differentiated tumor, lymphovascular invasion (LVI) and perineural invasion (PNI) than patients with lower yp-stages. We found that yp-stage, preoperative CEA, LVI, PNI and tumor regression grade were significant prognostic factors for both local and systemic recurrence. In multivariate analysis, yp-stage, LVI and PNI were significant factors for local and systemic recurrence. During the median follow-up of 37.5 months, the five-year local recurrence-free survival rate was 100.0%, 95.0%, 89.3%, and 80.6% of yp-stage 0?Ⅲ, respectively. The five-year systemic recurrence-free survival was 95.8%, 75.3%, 71.4%, and 48.8% of yp-stages 0?Ⅲ, respectively.
Conclusion: The yp-stage after preoperative CRT for rectal cancer is closely correlated with local and systemic recurrencefree survival. Therefore, yp-stage should be considered as a prognostic factor for rectal cancer patients having a course of preoperative CRT.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (19)
참고문헌 신청
1. [학술지(정기간행물)] - Kapiteijn E. / 2001 / Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer / N Engl J Med 345 : 638 ~ 646
2. [학술지(정기간행물)] - Sauer R. / 2004 / Preoperative versus postoperative chemoradiotherapy for rectal cancer / N Engl J Med 351 : 1731 ~ 1740
3. [학술지(정기간행물)] - Huh JW. / 2013 / Clinical prediction of pathological complete response after preoperative chemoradiotherapy for rectal cancer / Dis Colon Rectum 56 : 698 ~ 703
4. [학술지(정기간행물)] - Lee YC. / 2013 / Prognostic significance of partial tumor regression after preoperative chemoradiotherapy for rectal cancer : a meta-analysis / Dis Colon Rectum 56 : 1093 ~ 1101
5. [학술지(정기간행물)] - Roy P. / 2012 / The prognostic value of grade of regression and oncocytic change in rectal adenocarcinoma treated with neo-adjuvant chemoradiotherapy / J Surg Oncol 105 : 130 ~ 134
2. [학술지(정기간행물)] - Sauer R. / 2004 / Preoperative versus postoperative chemoradiotherapy for rectal cancer / N Engl J Med 351 : 1731 ~ 1740
3. [학술지(정기간행물)] - Huh JW. / 2013 / Clinical prediction of pathological complete response after preoperative chemoradiotherapy for rectal cancer / Dis Colon Rectum 56 : 698 ~ 703
4. [학술지(정기간행물)] - Lee YC. / 2013 / Prognostic significance of partial tumor regression after preoperative chemoradiotherapy for rectal cancer : a meta-analysis / Dis Colon Rectum 56 : 1093 ~ 1101
5. [학술지(정기간행물)] - Roy P. / 2012 / The prognostic value of grade of regression and oncocytic change in rectal adenocarcinoma treated with neo-adjuvant chemoradiotherapy / J Surg Oncol 105 : 130 ~ 134
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UCI(KEPA) : I410-ECN-0101-2016-514-001071534