지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
- 수록면
- 58 - 65 (8page)
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초록· 키워드
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Purpose: This study was performed to evaluate the effect of chitosan combined with absorbable gelatin compressed sponge on the expression of osteoblastic differentiation marker genes during the healing of rat extraction socket.
Materials and Methods: Twenty-four male Wistar rats were used. In control group, the extraction socket was closed with suture. In chitosan group, the socket was filled with chitosan combined with Gelfoam (Pharmacia & Upjohn Co.) and closed with suture. In each group, the animals were sacrificed at 3 days, 1 week, 2 weeks, and 4 weeks postoperatively. The expression of osteoblastic differentiation marker genes, including BSP, OCN, Runx2, and Col1 were quantified by real-time polymerase chain reaction.
Result: Compared to control group, the mRNA level of BSP in chitosan group increased significantly at 2 weeks after extraction and the level of OCN decreased significantly at 3 days and 4 weeks after extraction (P<0.05). The mRNA levels of OCN, Runx2, and Col1 in chitosan group increased slightly at 2 weeks after extraction, but there was no statistical difference between groups.
Conclusion: The results indicate that chitosan has some effects on the expression of osteogenic genes during the healing of extraction sockets.
Materials and Methods: Twenty-four male Wistar rats were used. In control group, the extraction socket was closed with suture. In chitosan group, the socket was filled with chitosan combined with Gelfoam (Pharmacia & Upjohn Co.) and closed with suture. In each group, the animals were sacrificed at 3 days, 1 week, 2 weeks, and 4 weeks postoperatively. The expression of osteoblastic differentiation marker genes, including BSP, OCN, Runx2, and Col1 were quantified by real-time polymerase chain reaction.
Result: Compared to control group, the mRNA level of BSP in chitosan group increased significantly at 2 weeks after extraction and the level of OCN decreased significantly at 3 days and 4 weeks after extraction (P<0.05). The mRNA levels of OCN, Runx2, and Col1 in chitosan group increased slightly at 2 weeks after extraction, but there was no statistical difference between groups.
Conclusion: The results indicate that chitosan has some effects on the expression of osteogenic genes during the healing of extraction sockets.
목차
Introduction
Materials and Methods
Result
Discussion
Conclusion
References
참고문헌 (35)
참고문헌 신청
1. [학술지(정기간행물)] - Schropp L / 2003 / Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study / Int J Periodontics Restorative Dent 23 : 313 ~ 323
2. [학술지(정기간행물)] - Evian CI / 1982 / The osteogenic activity of bone removed from healing extraction sockets in humans / J Periodontol 53 : 81 ~ 85
3. [학술지(정기간행물)] - Cardaropoli G / 2005 / Healing of extraction sockets and surgically produced--augmented and nonaugmented--defects in the alveolar ridge. An experimental study in the dog / J Clin Periodontol 32 : 435 ~ 440
4. [학술지(정기간행물)] - Schmitz JP / 1986 / The critical size defect as an experimental model for craniomandibulofacial nonunions / Clin Orthop Relat Res (205) : 299 ~ 308
5. [학술지(정기간행물)] - Yen AH / 2008 / Stem cells and tooth tissue engineering / Cell Tissue Res 331 : 359 ~ 372
2. [학술지(정기간행물)] - Evian CI / 1982 / The osteogenic activity of bone removed from healing extraction sockets in humans / J Periodontol 53 : 81 ~ 85
3. [학술지(정기간행물)] - Cardaropoli G / 2005 / Healing of extraction sockets and surgically produced--augmented and nonaugmented--defects in the alveolar ridge. An experimental study in the dog / J Clin Periodontol 32 : 435 ~ 440
4. [학술지(정기간행물)] - Schmitz JP / 1986 / The critical size defect as an experimental model for craniomandibulofacial nonunions / Clin Orthop Relat Res (205) : 299 ~ 308
5. [학술지(정기간행물)] - Yen AH / 2008 / Stem cells and tooth tissue engineering / Cell Tissue Res 331 : 359 ~ 372
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UCI(KEPA) : I410-ECN-0101-2016-515-001061980