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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.19 No.4
- 발행연도
- 2014.12
- 수록면
- 321 - 326 (6page)
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In this study, we developed a method to quantify esculetin (6,7-dihydroxycoumarin) in plasma and tissues using HPLC coupled with ultraviolet detection and measured the level of esculetin in rat plasma after oral administration. The calibration curve for esculetin was linear in the range of 4.8 ng/mL to 476.2 ng/mL, with a correlation coefficient (r²) of 0.996, a limit of detection value of 33.2 ng/mL, and a limit of quantification value of 100.6 ng/mL. Recovery rates for the 95.2 ng/mL and 190.5 ng/mL samples were 95.2% and 100.3%, within-runs and 104.8% and 101.0% between-runs, respectively. The relative standard deviation was less than 7% for both runs. In the pharmacokinetic analysis, the peak plasma esculetin level was reached 5 min after administration (Cmax=173.3 ng/mL; T<SUB>1/2</SUB>=45 min; AUC<SUB>0∼180 min</SUB>=5,167.5 ngㆍmin/mL). At 180 min post-administration (i.e., after euthanasia), esculetin was only detectable in the liver (30.87±11.33 ng/g) and the kidney (20.29±7.02 ng/g).
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (18)
참고문헌 신청
1. [학술지(정기간행물)] - Zhou L / 2008 / Simultaneous analysis of coumarins and secoiridoids in Cortex Fraxini by high-performance liquid chromatography−diode array detection−electrospray ionization tandem mass spectrometry / J Pharm Biomed Anal 47 : 39 ~ 46
2. [학술지(정기간행물)] - Kemal C / 1987 / Reductive inactivation of soybean lipoxygenase 1 by catechols: a possible mechanism for regulation of lipoxygenase activity / Biochemistry 26 : 7064 ~ 7072
3. [학술지(정기간행물)] - Okada Y / 1995 / Search for naturally occurring substances to prevent the complications of diabetes. II. Inhibitory effect of coumarin and flavonoid derivatives on bovine lens aldose reductase and rabbit platelet aggregation / Chem Pharm Bull (Tokyo) 43 : 1385 ~ 1387
4. [학술지(정기간행물)] - Wang SY / 2000 / Antioxidant activity in fruits and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental stage / J Agric Food Chem 48 : 140 ~ 146
5. [학술지(정기간행물)] - Wang F / 2002 / Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils / Nat Cell Biol 4 : 513 ~ 518
2. [학술지(정기간행물)] - Kemal C / 1987 / Reductive inactivation of soybean lipoxygenase 1 by catechols: a possible mechanism for regulation of lipoxygenase activity / Biochemistry 26 : 7064 ~ 7072
3. [학술지(정기간행물)] - Okada Y / 1995 / Search for naturally occurring substances to prevent the complications of diabetes. II. Inhibitory effect of coumarin and flavonoid derivatives on bovine lens aldose reductase and rabbit platelet aggregation / Chem Pharm Bull (Tokyo) 43 : 1385 ~ 1387
4. [학술지(정기간행물)] - Wang SY / 2000 / Antioxidant activity in fruits and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental stage / J Agric Food Chem 48 : 140 ~ 146
5. [학술지(정기간행물)] - Wang F / 2002 / Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils / Nat Cell Biol 4 : 513 ~ 518
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