지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.19 No.4
- 발행연도
- 2014.12
- 수록면
- 247 - 260 (14page)
이용수
초록· 키워드
오류제보하기
The impact of folate on health and disease, particularly pregnancy complications and congenital malformations, has been extensively studied. Mandatory folic acid fortification therefore has been implemented in multiple countries, resulting in a reduction in the occurrence of neural tube defects. However, emerging evidence suggests increased folate intake may also be associated with unexpected adverse effects. This literature review focuses on contemporary issues of concern, and possible underlying mechanisms as well as giving consideration the future direction of mandatory folic acid fortification. Folate fortification has been associated with the presence of unmetabolized folic acid (PteGlu) in blood, masking of vitamin B<SUB>12</SUB> deficiency, increased dosage for anti-cancer medication, photo-catalysis of PteGlu leading to potential genotoxicity, and a role in the pathoaetiology of colorectal cancer. Increased folate intake has also been associated with twin birth and insulin resistance in offspring, and altered epigenetic mechanisms of inheritance. Although limited data exists to elucidate potential mechanisms underlying these issues, elevated blood folate level due to the excess use of PteGlu without consideration of an individual"s specific phenotypic traits (e.g. genetic background and undiagnosed disease) may be relevant. Additionally, the accumulation of unmetabolized PteGlu may lead to inhibition of dihydrofolate reductase and other enzymes. Concerns notwithstanding, folic acid fortification has achieved enormous advances in public health. It therefore seems prudent to target and carefully monitor high risk groups, and to conduct well focused further research to better understand and to minimize any risk of mandatory folic acid fortification.
목차
ABSTRACT
INTRODUCTION
FOLIC ACID ABSORPTION AND DIHYDROFOLATE REDUCTASE
BACKGROUND TO THE IMPLEMENTATION OF MANDATORY FOLIC ACID FORTIFICATION
MANDATORY FOLIC ACID FORTIFICATION POLICIES IN SELECTED COUNTRIES
IMPROVED BLOOD FOLATE LEVEL AND DECREASED OCCURRENCE OF NEURAL TUBE DEFECTS
THE CONTROVERSY OF POTENTIAL ADVERSE EFFECTS OF EXCESS FOLIC ACID
CONCLUSION
REFERENCES
참고문헌 (179)
참고문헌 신청
1. [학술지(정기간행물)] - Zhang S / 1999 / A prospective study of folate intake and the risk of breast cancer / JAMA 281 : 1632 ~ 1637
2. [학술지(정기간행물)] - Giovannucci EL / 1998 / Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study / Ann Intern Med 129 : 517 ~ 524
3. [학술지(정기간행물)] - Kim J / 2009 / Folate intake and the risk of colorectal cancer in a Korean population / Eur J Clin Nutr 63 : 1057 ~ 1064
4. [학술지(정기간행물)] - Yang D / 2013 / Dietary intake of folate, B-vitamins and methionine and breast cancer risk among Hispanic and non-Hispanic white women / PLoS One 8 : e54495 ~
5. [학술지(정기간행물)] - Quadri P / 2004 / Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia / Am J Clin Nutr 80 : 114 ~ 122
2. [학술지(정기간행물)] - Giovannucci EL / 1998 / Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study / Ann Intern Med 129 : 517 ~ 524
3. [학술지(정기간행물)] - Kim J / 2009 / Folate intake and the risk of colorectal cancer in a Korean population / Eur J Clin Nutr 63 : 1057 ~ 1064
4. [학술지(정기간행물)] - Yang D / 2013 / Dietary intake of folate, B-vitamins and methionine and breast cancer risk among Hispanic and non-Hispanic white women / PLoS One 8 : e54495 ~
5. [학술지(정기간행물)] - Quadri P / 2004 / Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia / Am J Clin Nutr 80 : 114 ~ 122
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2016-594-001045030