지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
- 수록면
- 237 - 243 (7page)
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초록· 키워드
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Triglyceride (TG) can cause death of macrophages and formation of foam cells thereby increasing inflammation in atherosclerotic plaques. Accumulation of cholesterol in macrophages is another critical event that promotes development of inflammatory cardiovascular diseases. Several proteins are known to transport intracellular cholesterol outside of the cell and these proteins are thought to be protective against atherosclerosis pathogenesis. It is unknown whether TG can affect cholesterol efflux in macrophages. In the current study, we examined mRNA expression levels of genes that promote efflux of cholesterol (ABCA1, ABCG1 and SR-B1). We found that TG treated THP-1 macrophages exhibited an increase in ABCG1 expression in a dose- and time-dependent manner. In contrast, the expression of ABCA1 and SR-B1 remained unchanged. To identify cell signaling pathways that participate in up-regulation of ABCG1, THP-1 macrophages were treated with various cell signaling inhibitors. We found that inhibition of the JNK and p38 MAPK pathway completely abrogated up-regulation of ABCG1 whereas inhibition of MEK1 further enhanced ABCG1 expression in TG treated THP-1 macrophages. Also, TG induced phosphorylation of JNK and p38 MAPK in THP-1 macrophages. These results suggest that TG may potentially influence cholesterol efflux in macrophages.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (24)
참고문헌 신청
1. [학술지(정기간행물)] - Aronis A / 2005 / Mechanism underlying oxidative stress-mediated lipotoxicity: Exposure of J774.2 macrophages to triacylglycerols facilitates mitochondrial reactive oxygen species production and cellular necrosis / Free Radical Bio Med 38 : 1221 ~ 1230
2. [학술지(정기간행물)] - Calkin AC / 2010 / Liver X receptor signaling pathways and atherosclerosis / Arterioscler Thromb Vasc Biol 30 : 1513 ~ 1518
3. [학술지(정기간행물)] - Daniels TF / 2009 / Lipoproteins, cholesterol homeostasis and cardiac health / Int J Biol Sci 5 : 474 ~ 488
4. [학술지(정기간행물)] - Dean M / 2001 / The human ATP-binding cassette (ABC) transporter superfamily / Genome Res 11 : 1156 ~ 1166
5. [학술지(정기간행물)] - Feingold KR / 2012 / Mechanisms of trigly-ceride accumulation in activated macrophages / J Leukoc Biol 92 : 829 ~ 839
2. [학술지(정기간행물)] - Calkin AC / 2010 / Liver X receptor signaling pathways and atherosclerosis / Arterioscler Thromb Vasc Biol 30 : 1513 ~ 1518
3. [학술지(정기간행물)] - Daniels TF / 2009 / Lipoproteins, cholesterol homeostasis and cardiac health / Int J Biol Sci 5 : 474 ~ 488
4. [학술지(정기간행물)] - Dean M / 2001 / The human ATP-binding cassette (ABC) transporter superfamily / Genome Res 11 : 1156 ~ 1166
5. [학술지(정기간행물)] - Feingold KR / 2012 / Mechanisms of trigly-ceride accumulation in activated macrophages / J Leukoc Biol 92 : 829 ~ 839
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UCI(KEPA) : I410-ECN-0101-2016-510-001024242