지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
- 수록면
- 221 - 226 (6page)
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초록· 키워드
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High-density lipoprotein (HDL) cholesterol levels are associated with decreased risk of coronary artery disease. Several genome-wide association studies (GWAS) for HDL cholesterol levels have implicated Lipoprotein lipase (LPL) as possibly being causal. Herein, the association between single nucleotide polymorphism (SNP) rs10503669 in the LPL gene and HDL cholesterol levels and triglyceride levels was tested in the Korean population. A total of 994 subjects from Seoul City were included in a replication study with LPL SNP rs10503669. SNP rs10503669 in the LPL gene was associated with mean HDL cholesterol levels (effect per allele 3.13 mg/dL, P<0.0001) and triglyceride levels (effect per allele -18.0 mg/dL, P=0.0026). Subjects with the CA/AA genotype had a 0.42-fold (range 0.23~0.77-fold) lower risk of having abnormal HDL cholesterol levels (<40 mg/dL) than subjects with the CC genotype. When analyzed by gender, the association of LPL was stronger in men than in women. This study clearly demonstrates that genetic variants in LPL influence HDL cholesterol levels and triglyceride levels in Korean adults.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (23)
참고문헌 신청
1. [학술지(정기간행물)] - Ahmad T / 2011 / Physical activity modifies the effect of LPL, LIPC, and CETP polymorphisms on HDL-C levels and the risk of myocardial infarction in women of European ancestry / Circ Cardiovasc Genet 4 : 74 ~ 80
2. [학술지(정기간행물)] - Assmann G / 2004 / HDL cholesterol and protective factors in atherosclerosis / Circulation 109 : III8 ~ III14
3. [학술지(정기간행물)] - Aulchenko YS / 2009 / ENGAGE Consortium. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts / Nat Genet 41 : 47 ~ 55
4. [학술지(정기간행물)] - Deeb SS / 1989 / Structure of the human lipoprotein lipase gene / Biochemistry 28 : 4131 ~ 4135
5. [학술지(정기간행물)] - Monsalve MV / 1990 / A missense mutation at codon 188 of the human lipoprotein lipase gene is a frequent cause of lipoprotein lipase deficiency in persons of different ancestries / J Clin Invest 86 : 728 ~ 734
2. [학술지(정기간행물)] - Assmann G / 2004 / HDL cholesterol and protective factors in atherosclerosis / Circulation 109 : III8 ~ III14
3. [학술지(정기간행물)] - Aulchenko YS / 2009 / ENGAGE Consortium. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts / Nat Genet 41 : 47 ~ 55
4. [학술지(정기간행물)] - Deeb SS / 1989 / Structure of the human lipoprotein lipase gene / Biochemistry 28 : 4131 ~ 4135
5. [학술지(정기간행물)] - Monsalve MV / 1990 / A missense mutation at codon 188 of the human lipoprotein lipase gene is a frequent cause of lipoprotein lipase deficiency in persons of different ancestries / J Clin Invest 86 : 728 ~ 734
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UCI(KEPA) : I410-ECN-0101-2016-510-001024222