지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
- 수록면
- 209 - 220 (12page)
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초록· 키워드
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Vascular endothelial growth factor (VEGF) is a key factor involved in the induction of angiogenesis and has become an attractive target for anti-angiogenesis therapies. The purpose of this study was to elucidate the anti-angiogenic activity of Rubus coreanus Miquel water extract (RCME). Rubus coreanus Miquel has long been employed as a traditional medicine, and recent studies have demonstrated that it has measureable biological activities. Thus, we investigated for the first time the effect of RCME on angiogenesis and its underlying signaling pathways. The effects of RCME were tested on in vitro models of angiogenesis, namely, proliferation, migration, invasion and tube formation of human umbilical vein endothelial cells as well as an ex vivo model of vessel sprouting from the rat aorta in response to VEGF. We observed that VEGF-induced angiogenesis was strongly suppressed by RCME treatment compared to that of the control group. Moreover, we found that RCME inhibited VEGF-induced activation of matrix metalloproteinases and phosphorylation of extracellular signal-regulated kinase and p38, and also effectively inhibited phosphorylation of VEGF receptor 2. These results indicated that RCME inhibits angiogenesis by suppressing phosphorylation of the VEGF receptor and may be useful for the treatment of angiogenesis-dependent diseases such as cancer and diabetic retinopathy.
목차
INTRODUCTION
MATERIAL AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (45)
참고문헌 신청
1. [학술지(정기간행물)] - Agarwal R / 2006 / Anticancer potential of silymarin: from bench to bed side / Anticancer Res 26 : 4457 ~ 4498
2. [학술지(정기간행물)] - Albini A / 1987 / A rapid in vitro assay for quantitating the invasive potential of tumor cells / Cancer Res 47 : 3239 ~ 3245
3. [학술지(정기간행물)] - Balbay MD / 1999 / Highly metastatic human prostate cancer growing within the prostate of athymic mice overexpresses vascular endothelial growth factor / Clin Cancer Res 5 : 783 ~ 789
4. [학술지(정기간행물)] - Bussolino F / 1997 / Molecular mechanisms of blood vessel formation / Trends Biochem Sci 22 : 251 ~ 256
5. [학술지(정기간행물)] - Cardenas C / 2011 / Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene / PLoS One 6 : e23407 ~
2. [학술지(정기간행물)] - Albini A / 1987 / A rapid in vitro assay for quantitating the invasive potential of tumor cells / Cancer Res 47 : 3239 ~ 3245
3. [학술지(정기간행물)] - Balbay MD / 1999 / Highly metastatic human prostate cancer growing within the prostate of athymic mice overexpresses vascular endothelial growth factor / Clin Cancer Res 5 : 783 ~ 789
4. [학술지(정기간행물)] - Bussolino F / 1997 / Molecular mechanisms of blood vessel formation / Trends Biochem Sci 22 : 251 ~ 256
5. [학술지(정기간행물)] - Cardenas C / 2011 / Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene / PLoS One 6 : e23407 ~
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UCI(KEPA) : I410-ECN-0101-2016-510-001024217