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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.9
- 수록면
- 162 - 167 (6page)
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Tuberculosis (TB) is one of the major global health problems and it has been estimated that in 5~10% of Mycobacterium tuberculosis (MTB)-infected individuals, the infection progresses to an active disease. Numerous cytokines and chemokines regulate immunological responses at cellular level including stimulation and recruitment of wide range of cells in immunity and inflammation. In the present study, the mRNA expression levels of eight host immune markers containing of IFN-γ, TNF-α, IL-2R, IL-4, IL-10, CXCL9, CXCL10, and CXCL11 in whole blood cells from active pulmonary TB patients were measured after T-cell mitogen (PHA) and MTB specific antigens (ESAT-6, CFP-10, and TB7.7). Among the TH1-type factors, IFN-γ mRNA expression was peaked at 4 h, TNF-α and IL-2R mRNA expression was significantly high at the late time points (24 h) in active TB patients, TH2-type cytokine (IL4 and IL10) mRNA expression levels in both active TB and healthy controls samples did not changed significantly, and the mRNA expression of the three IFN-γ-induced chemokines (CXCL9, CXCL10, and CXCL11) were peaked at the late time points (24 h) in active TB patients after MTB specific antigen stimulation. In conclusion, the mRNA expression patterns of the TB-related immune markers in response to the T-cell mitogen (PHA) differed from those in response to MTB specific antigens and these findings may helpful for understanding the relationship between MTB infection and host immune markers in a transcripts level.
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참고문헌 (21)
참고문헌 신청
1. [학술지(정기간행물)] - Adane M / 2013 / Cytokines and Chemokines as Biomarkers of Tuberculosis / J Mycobac Dis 3 : 1 ~ 4
2. [학술지(정기간행물)] - Azzurri A / 2005 / IFN-gamma inducible protein 10 and pentraxin 3 plasma levels are tools for monitoring inflammation and disease activity in Mycobacterium tuberculosis infection / Microbes Infect 7 : 1 ~ 8
3. [학술지(정기간행물)] - Behr MA / 1999 / Comparative genomics of BCG vaccines by whole genome DNA microarray / Science 284 : 1520 ~ 1523
4. [학술지(정기간행물)] - Brosch R / 2002 / A new evolutionary scenario for the Mycobacterium tuberculosis complex / Proc Natl Acad Sci USA 99 : 3684 ~ 3689
5. [학술지(정기간행물)] - Cole ST / 1998 / Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence / Nature 393 : 537 ~ 544
2. [학술지(정기간행물)] - Azzurri A / 2005 / IFN-gamma inducible protein 10 and pentraxin 3 plasma levels are tools for monitoring inflammation and disease activity in Mycobacterium tuberculosis infection / Microbes Infect 7 : 1 ~ 8
3. [학술지(정기간행물)] - Behr MA / 1999 / Comparative genomics of BCG vaccines by whole genome DNA microarray / Science 284 : 1520 ~ 1523
4. [학술지(정기간행물)] - Brosch R / 2002 / A new evolutionary scenario for the Mycobacterium tuberculosis complex / Proc Natl Acad Sci USA 99 : 3684 ~ 3689
5. [학술지(정기간행물)] - Cole ST / 1998 / Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence / Nature 393 : 537 ~ 544
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