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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.9
- 수록면
- 103 - 110 (8page)
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초록· 키워드
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Matrix metalloproteinases (MMPs), also called matrixins, function in the extracellular environment of cells and degrade both matrix and non-matrix proteins. They are multidomain proteins and their activities are regulated by tissue inhibitor of metalloproteinases (TIMPs). The uncontrolled regulation of MMPs is involved in various pathologic processes, such as tumor invasion, migration, host immune escape, extravasation, angiogenesis, and tumor growth. Especially, matrix metalloproteinase-9 (MMP-9) is one of the metastasis-accelerating genes involved in metastasis of various types of human cancers. Here, we review the member of MMP family and discusses their domain structure and function, enzyme activation, the mechanism of inhibition by TIMPs. In particular, we focus the role of MMP-9 in relation to cancer metastasis.
목차
INTRODUCTION
Tumor cell metastasis
The MMP family
Classes of MMPs inhibitors
MMP-9 and tumor metastasis
Concluding remarks
REFERENCES
참고문헌 (40)
참고문헌 신청
1. [학술지(정기간행물)] - Baker AH / 2002 / Metalloproteinase inhibitors: biological actions and therapeutic opportunities / J Cell Sci 115 : 3719 ~ 3727
2. [학술지(정기간행물)] - Bernhard EJ / 1995 / The effect of E1A transfection on MMP-9 expression and metastatic potential / Int J Cancer 60 : 718 ~ 724
3. [학술지(정기간행물)] - Birkedal-Hansen H / 1995 / Proteolytic remodeling of extracellular matrix / Curr Opin Cell Biol 7 : 728 ~ 735
4. [학술지(정기간행물)] - Birkedal-Hansen H / 1993 / Matrix metalloproteinases: a review / Crit Rev Oral Biol Med 4 : 197 ~ 250
5. [학술지(정기간행물)] - Bjorklund M / 2005 / Gelatinase-mediated migration and invasion of cancer cells / Biochim Biophys Acta 1755 : 37 ~ 69
2. [학술지(정기간행물)] - Bernhard EJ / 1995 / The effect of E1A transfection on MMP-9 expression and metastatic potential / Int J Cancer 60 : 718 ~ 724
3. [학술지(정기간행물)] - Birkedal-Hansen H / 1995 / Proteolytic remodeling of extracellular matrix / Curr Opin Cell Biol 7 : 728 ~ 735
4. [학술지(정기간행물)] - Birkedal-Hansen H / 1993 / Matrix metalloproteinases: a review / Crit Rev Oral Biol Med 4 : 197 ~ 250
5. [학술지(정기간행물)] - Bjorklund M / 2005 / Gelatinase-mediated migration and invasion of cancer cells / Biochim Biophys Acta 1755 : 37 ~ 69
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