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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
Jianhua Hou (Jilin University) Yanze Chen (Jilin University) Xiuping Meng (Jilin University) Ce Shi (Jilin University) Chen Li (Jilin University) Yuanping Chen (Jilin University) Hongchen Sun (Jilin University)
저널정보
대한치과교정학회 대한치과교정학회지 대한치과교정학회지 제44권 제6호
발행연도
2014.11
수록면
320 - 329 (10page)

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초록· 키워드

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Objective: To investigate the involvement of ephrinB2 in periodontal tissue remodeling in compression areas during orthodontic tooth movement and the effects of compressive force on EphB4 and ephrinB2 expression in osteoblasts and osteoclasts. Methods: A rat model of experimental tooth movement was established to examine the histological changes and the localization of ephrinB2 in compressed periodontal tissues during experimental tooth movement. RAW264.7 cells and ST2 cells, used as precursor cells of osteoclasts and osteoblasts, respectively, were subjected to compressive force in vitro. The gene expression of EphB4 and ephrinB2, as well as bone-associated factors including Runx2, Sp7, NFATc1, and calcitonin receptor, were examined by quantitative real-time polymerase chain reaction (PCR). Results: Histological examination of the compression areas of alveolar bone from experimental rats showed that osteoclastogenic activities were promoted while osteogenic activities were inhibited. Immunohistochemistry revealed that ephrinB2 was strongly expressed in osteoclasts in these areas. Quantitative real-time PCR showed that mRNA levels of NFATc1, calcitonin receptor, and ephrinB2 were increased significantly in compressed RAW264.7 cells, and the expression of ephrinB2, EphB4, Sp7, and Runx2 was decreased significantly in compressed ST2 cells. Conclusions: Our results indicate that compressive force can regulate EphB4 and ephrinB2 expression in osteoblasts and osteoclasts, which might contribute to alveolar bone resorption in compression areas during orthodontic tooth movement.
#Tooth movement #Bone biology #Cell/molecular biology #EphrinB2 #EphB4

목차

INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
CONCLUSION
REFERENCES

참고문헌 (30)

참고문헌 신청
1. [학술지(정기간행물)] - Krishnan V / 2006 / Cellular, molecular, and tissue-level reactions to orthodontic force / Am J Orthod Dentofacial Orthop 129 : 469.e1 ~ 469.e32 google schola 2. [학술지(정기간행물)] - Wise GE / 2008 / Mechanisms of tooth eruption and orthodontic tooth movement / J Dent Res 87 : 414 ~ 434 google schola 3. [학술지(정기간행물)] - Masella RS / 2006 / Current concepts in the biology of orthodontic tooth movement / Am J Orthod Dentofacial Orthop 129 : 458 ~ 468 google schola 4. [학술지(정기간행물)] - Roberts WE / 2004 / Bone modeling:biomechanics, molecular mechanisms, and clinical perspectives / Sem Orthod 10 : 123 ~ 161 google schola 5. [학술지(정기간행물)] - Oshiro T / 2002 / Osteoclast induction in periodontal tissue during experimental movement of incisors in osteoprotegerin-deficient mice / Anat Rec 266 : 218 ~ 225 google schola

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UCI(KEPA) : I410-ECN-0101-2015-510-002849352