IgG Avidity Antibodies against Toxoplasma gondii in High Risk Females of Reproductive Age Group in India

Naushaba Siddiqui; Fatima Shujatullah; Haris M. Khan; Tamkin Rabbani; Parvez A. Khan

추천

검색

질문

자료유형: 학술저널

저자정보: Naushaba Siddiqui (Jawaharlal Nehru Medical College and Hospital) Fatima Shujatullah (Jawaharlal Nehru Medical College and Hospital) Haris M. Khan (Jawaharlal Nehru Medical College and Hospital) Tamkin Rabbani (Jawaharlal Nehru Medical College and Hospital) Parvez A. Khan (Jawaharlal Nehru Medical College and Hospital)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.52 No.5

발행연도: 2014.10

수록면: 487 - 491 (5page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Toxoplasma gondii is an obligate intracellular protozoan that is distributed worldwide. Recently, several tests for avidity of Toxoplasma IgG antibodies have been introduced to help discriminate between recently acquired and distant infections. The study was conducted in Jawaharlal Nehru Medical College and Hospital, India from February 2011 to September 2012. Serum specimens were subjected to Toxoplasma IgM ELISA and IgG avidity ELISA test. Out of 48 patients with abortions, 17 (35.4%) were positive for IgM ELISA, and 8 (16.6%) had low IgG avidity antibodies. Out of 48 patients with other obstetric problems, 23 (47.9%) were positive for IgM ELISA, and 17 (35.4%) had low IgG avidity antibodies. Combining both groups on avidity test, only 25 of 40 (62.5 %) IgM-positive women had low-avidity IgG antibodies suggesting a recent T. gondii infection in these women. More importantly, 15 (37.5%) of the IgM-positive women had high-avidity antibodies suggesting that the infection was acquired before gestation The relation of IgM seropositivity with the following risk factors was not found to be statistically significant; contact with cats (0.13), non-vegetarian food habits (0.05), and low socio-economic status (0.49). While, for IgG avidity ELISA, only contact with cats (0.01) was significantly associated with seropositivity. All other risk factors have P-values of >0.05 (not significant). IgG avidity test when used in combination with IgM test was a valuable assay for diagnosis of ongoing or recently acquired T. gondii infection in India.

#Toxoplasma gondii #toxoplasmosis #IgG avidity test #high risk pregnant women #India

참고문헌 (18)

참고문헌 신청

Dumetrè A / 2003 / How to detect Toxoplasma gondii oocysts in environmental samples / FEMS Microbiol Rev 27:651~661

Hill D / 2002 / Toxoplasma gondii;transmission, diagnosis and prevention / Clin Microbiol Infect 8:634~640

Sukhtana Y / 2006 / Toxoplasmosis : beyond animals to humans / Trends Parasitol 22:137~142

Sarkar MD / 2012 / Seropositivity of toxoplasmosis in antenatal women with bad obstetric history in a tertiary-care hospital of Andhra Pradesh, India / J Health Popul Nutr 30:87~92

Aral Akarsu G / 2011 / Retrospective evaluation of Toxoplasma gondii seropositivity in fertile and infertile women / Mikrobiyol Bult 45:174~180