지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.9
- 수록면
- 95 - 103 (9page)
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초록· 키워드
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Although formaldehyde (FA) is known to be a major allergen responsible for allergic contact dermatitis, there are conflicting reports regarding correlation between FA exposure and interleukin (IL-4) expression. To investigate whether allergic responses including IL-4 expression were induced by repeated dermal exposure to low dose FA, alterations in the luciferase signal and allergic phenotypes were measured in IL- 4/Luc/CNS-1 transgenic (Tg) mice containing luciferase cDNA under control of the IL-4 promoter after exposure to 4% FA for 2 weeks. High levels of luciferase were detected in the abdominal region of the whole body and submandibular lymph node (SLN) of FA treated mice. Additionally, the ear thickness and IgE concentration were significantly upregulated in the FA treated group when compared with the acetone olive oil (AOO) treated group. FA treated mice showed enhanced auricular lymph node (ALN) weight, epidermis and dermis thickness, and infiltration of inflammatory cells. Furthermore, the expression of IL-6 among T helper 2 cytokines was higher in the FA treated group than the AOO treated group, while vascular endothelial growth factor (VEGF) levels remained constant. Overall, the results presented herein provide additional evidence that various allergic responses may be successfully induced in IL-4/Luc/CNS-1 Tg mice after exposure to low dose FA for 2 weeks. The luciferase signal under the IL-4 promoter may reflect general indicators of the allergic response induced by exposure to low dose FA.
목차
Materials and Methods
Results
Discussion
References
참고문헌 (17)
참고문헌 신청
1. [단행본] - Günther R. / 2002 / Formaldehyde. Ullmann’s Encyclopedia of Industrial Chemistry / WileyVCH
2. [학술지(정기간행물)] - Marzulli FN. / 1974 / The use of graded concentrations in studying skin sensitizers : experimental contact sensitization in man / Food Cosmet Toxicol 12 (2) : 219 ~ 227
3. [학술지(정기간행물)] - Nethercott JR. / 1988 / Contact dermatitis in funeral service workers / Contact Dermatitis 18 (5) : 263 ~ 267
4. [학술지(정기간행물)] - Dearman RJ. / 1999 / Comparison of cytokine secretion profiles provoked in mice by glutaraldehyde and formaldehyde / Clin Exp Allergy 29 (1) : 124 ~ 132
5. [학술지(정기간행물)] - Saneyoshi K. / 1997 / IL-4 and IL-6 production of bone marrow-derived mast cells is enhanced by treatment with environmental pollutants / Int Arch Allergy Immunol 114 (3) : 237 ~ 245
2. [학술지(정기간행물)] - Marzulli FN. / 1974 / The use of graded concentrations in studying skin sensitizers : experimental contact sensitization in man / Food Cosmet Toxicol 12 (2) : 219 ~ 227
3. [학술지(정기간행물)] - Nethercott JR. / 1988 / Contact dermatitis in funeral service workers / Contact Dermatitis 18 (5) : 263 ~ 267
4. [학술지(정기간행물)] - Dearman RJ. / 1999 / Comparison of cytokine secretion profiles provoked in mice by glutaraldehyde and formaldehyde / Clin Exp Allergy 29 (1) : 124 ~ 132
5. [학술지(정기간행물)] - Saneyoshi K. / 1997 / IL-4 and IL-6 production of bone marrow-derived mast cells is enhanced by treatment with environmental pollutants / Int Arch Allergy Immunol 114 (3) : 237 ~ 245
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UCI(KEPA) : I410-ECN-0101-2015-500-002710847