지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.8
- 수록면
- 523 - 531 (9page)
- DOI
- 10.21086/ksles.2014.08.21.4.523
이용수
초록· 키워드
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The purposes of this study were to examine the effects of exercise on cognitive function and the expression and correlation of MAP kinases (Mitogen-activated protein kinase; ERK1/2, JNK, p38) and MKP-1 (MAP kinase phosphatases-1) in the hippocampus of diabetic rats. streptozotocin-induced diabetic rats were divided into the control group (CG: n=10), the diabetic group (DG: n=10) and the diabetic with exercise group (DEG: n=10). The rats in DEG was made to treadmill exercise (5 days/week, 30min/day) for 6 weeks. It was showed that the results were a non-significant difference between the groups in the water maze task conducted to evaluate cognitive function, while the CG managed to reach the platform in a short period of time considering the distance travelled, while the DG took relatively more time than the CG. Although the DEG also took more time in comparison with the CG, it managed to reach the platform in a relatively shorter period of time in comparison to the DG. Expression of MAP kinase in the hippocampal tissues was significantly improved in the CG and the DEG, and the expression of MKP-1 that turns on/off the excessive expression of MAP kinase was also found to be significantly increased in the CG and the DEG in comparison to the DG (p<.05). In addition, according to the results of the analysis of correlation between MAP kinase and MKP-1 by using Pearson’s correlation coefficient, MKP-1 was found to have a highly significant correlation with JNK and p38 among the MAP kinase subfamilies (ERK1/2, JNK, p38) that accelerates cell death (p<.05). It is concluded that the effect of exercise to improve spatial cognitive function by affecting the expression of MAP kinase and MKP-1 involved in the signal transduction system of the hippocampus in diabetic rat.
목차
Abstract
1. Introduction
2. Method
3. Result
4. Discussion
5. Conclusion
REFERENCES
참고문헌 (37)
참고문헌 신청
1. [학술지(정기간행물)] - Baraban, J. M. / 1993 / Identification of p42 mitogenactivated protein kinase as a tyrosine kinase substrate activated by maximal electroconvulsive shock in hippocampus / Journal Of Neurochemistry 60 (1) : 330 ~ 336
2. [학술지(정기간행물)] - Bedford, T. G. / 1979 / Maximum oxygen consumption of rats and its changes with various experimentalprocedures / Journal of Applied Physiology 147 : 1278 ~ 1283
3. [학술지(정기간행물)] - Bhalla, U. S. / 2002 / MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network / Science 297 (5583) : 1018 ~ 1023
4. [학술지(정기간행물)] - Biessels, G. J. / 2005 / The impact of diabetes on cognition : what can be learned from rodent models? / Neurobiology of Aging 1 : 36 ~ 41
5. [학술지(정기간행물)] - Bohbot, V. D. / 1998 / Spatial memory deficits in patients with lesions to the right hippocampus and to the right para hippocampal cortex / Neuro psychologia 36 (11) : 1217 ~ 1238
2. [학술지(정기간행물)] - Bedford, T. G. / 1979 / Maximum oxygen consumption of rats and its changes with various experimentalprocedures / Journal of Applied Physiology 147 : 1278 ~ 1283
3. [학술지(정기간행물)] - Bhalla, U. S. / 2002 / MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network / Science 297 (5583) : 1018 ~ 1023
4. [학술지(정기간행물)] - Biessels, G. J. / 2005 / The impact of diabetes on cognition : what can be learned from rodent models? / Neurobiology of Aging 1 : 36 ~ 41
5. [학술지(정기간행물)] - Bohbot, V. D. / 1998 / Spatial memory deficits in patients with lesions to the right hippocampus and to the right para hippocampal cortex / Neuro psychologia 36 (11) : 1217 ~ 1238
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UCI(KEPA) : I410-ECN-0101-2015-500-002745593