지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.6
- 수록면
- 82 - 88 (7page)
이용수
초록· 키워드
오류제보하기
Objectives：The aim of our study was to investigate association of norepinephrine transporter gene (SLC6A2) polymorphism and side effects of osmotic-release oral system methylphenidate (OROS MPH) in children with attention-deficit hyperactivity disorder (ADHD).
Methods：We recruited drug naive children with ADHD (N=97). We administered OROS MPH by tolerable dosage. At week 8 of treatment, parents completed the Barkley’s side effect rating scale. We analyzed two SLC6A2 single nucleotide polymorphisms (SNPs), rs192303 and rs3785143, with blood of subjects. We compared the frequency and severity of each side effect among SLC6A2 genotypes of 2 SNPs.
Results：In the analysis of frequency of each side effect, irritability differed according to rs192303 and rs3785143 genotype. In comparisons of severity, talking less and disinterest differed according to rs192303 genotype. In the case of rs3785143, severities of disinterest and irritability were involved with genotype.
Conclusion：Side effects of OROS MPH showed an association with SLC6A2 genotype.
Methods：We recruited drug naive children with ADHD (N=97). We administered OROS MPH by tolerable dosage. At week 8 of treatment, parents completed the Barkley’s side effect rating scale. We analyzed two SLC6A2 single nucleotide polymorphisms (SNPs), rs192303 and rs3785143, with blood of subjects. We compared the frequency and severity of each side effect among SLC6A2 genotypes of 2 SNPs.
Results：In the analysis of frequency of each side effect, irritability differed according to rs192303 and rs3785143 genotype. In comparisons of severity, talking less and disinterest differed according to rs192303 genotype. In the case of rs3785143, severities of disinterest and irritability were involved with genotype.
Conclusion：Side effects of OROS MPH showed an association with SLC6A2 genotype.
목차
서론
방법
결과
고찰
결론
References
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Polanczyk G / 2007 / The worldwide prevalence of ADHD: a systematic review and metaregression analysis / Am J Psychiatry 164 : 942 ~ 948
2. [학술지(정기간행물)] - Vaughan B / 2012 / Pharmacotherapy of pediatric attentiondeficit/hyperactivity disorder / Child Adolesc Psychiatr Clin N Am 21 : 941 ~ 955
3. [학술지(정기간행물)] - Adler LD / 2010 / Review of medication adherence in children and adults with ADHD / Postgrad Med 122 : 184 ~ 191
4. [학술지(정기간행물)] - Toomey SL / 2012 / Why do children with ADHD discontinue their medication? / Clin Pediatr (Phila) 51 : 763 ~ 769
5. [학술지(정기간행물)] - Efron D / 1998 / Child and parent perceptions of stimulant medication treatment in attention deficit hyperactivity disorder / J Paediatr Child Health 34 : 288 ~ 292
2. [학술지(정기간행물)] - Vaughan B / 2012 / Pharmacotherapy of pediatric attentiondeficit/hyperactivity disorder / Child Adolesc Psychiatr Clin N Am 21 : 941 ~ 955
3. [학술지(정기간행물)] - Adler LD / 2010 / Review of medication adherence in children and adults with ADHD / Postgrad Med 122 : 184 ~ 191
4. [학술지(정기간행물)] - Toomey SL / 2012 / Why do children with ADHD discontinue their medication? / Clin Pediatr (Phila) 51 : 763 ~ 769
5. [학술지(정기간행물)] - Efron D / 1998 / Child and parent perceptions of stimulant medication treatment in attention deficit hyperactivity disorder / J Paediatr Child Health 34 : 288 ~ 292
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2015-510-002468446