지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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In this study, we investigated the effect of DMSO, a highly dipolar organic liquid, in collagen (5 μg/ml)-stimulated platelet aggregation. DMSO inhibited platelet aggregation at 0.5% by inhibiting production of thromboxane A₂ (TXA₂) which was associated with blocking cyclooxygenase (COX)-1 activity and TXA₂ synthase. In addition, DMSO significantly increased the formation of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP) and cyclic guanosine monophosphate (cGMP) from guanosine triphosphate (GTP). On the other hand, DMSO (0.1~0.5% concentration) did not affect the LDH release which indicates the cytotoxicity. Based on these results, DMSO has anti-platelet effect by regulation of several platelet signaling pathways, therefore we suggest that DMSO could be a novel strategy on many thrombotic disorders.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (28)
참고문헌 신청
1. [학술지(정기간행물)] - Abe T / 1995 / Rat kidney thromboxane receptor: molecular cloning, signal transduction, and intrarenal expression localization / J Clin Invest 96 : 657 ~ 664
2. [학술지(정기간행물)] - Asmis L / 2010 / DMSO inhibits human platelet activation through cyclooxygenase-1 inhibition. A novel agent for drug eluting stents? / Biochem Biophys Res Commun 391 : 1629 ~ 1633
3. [학술지(정기간행물)] - Bardutzky J / 2005 / Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model / J Cereb Blood Flow Metab 25 : 968 ~ 977
4. [학술지(정기간행물)] - Basch H / 1968 / In vitro antimicrobial activity of dimethylsulfoxide / Appl Microbiol 16 : 1953 ~ 1954
5. [학술지(정기간행물)] - Baumgartner HR / 1972 / Adhesion of platelets to subendothelium / Ann N Y Acad Sci 201 : 22 ~ 36
2. [학술지(정기간행물)] - Asmis L / 2010 / DMSO inhibits human platelet activation through cyclooxygenase-1 inhibition. A novel agent for drug eluting stents? / Biochem Biophys Res Commun 391 : 1629 ~ 1633
3. [학술지(정기간행물)] - Bardutzky J / 2005 / Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model / J Cereb Blood Flow Metab 25 : 968 ~ 977
4. [학술지(정기간행물)] - Basch H / 1968 / In vitro antimicrobial activity of dimethylsulfoxide / Appl Microbiol 16 : 1953 ~ 1954
5. [학술지(정기간행물)] - Baumgartner HR / 1972 / Adhesion of platelets to subendothelium / Ann N Y Acad Sci 201 : 22 ~ 36
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UCI(KEPA) : I410-ECN-0101-2015-500-001663705