Purpose: The aim of this study was examine effects of fatigue, anxiety, depression, social support, and spiritual well-being of supportive education program for hospice patients"s family. Method: Using a non-equivalent control group pre-post quasi-experimental design, 70 study subjects were assigned into two groups, experimental group (n=35) and the control group (n=35). Measures were fatigue, state-anxiety, depression, social support, and spiritual well-being to test for the effects of supportive education program for hospice patients"s family. Data analyzed using x² test, t-test with SPSS/WIN 19.0 version. Results: The experimental group receiving supportive education program for hospice patients"s family had a significant changes of fatigue, state-anxiety, depression, social support, and spiritual well-being. Conclusion: The supportive education program for hospice patients"s family is an effective intervention to enhance social support and spiritual well-being and to decrease fatigue, anxiety and depression.