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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.6
- 수록면
- 90 - 93 (4page)
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This study was performed to investigate the expression of two porcine endogenous retrovirus (PERV) elements, PERV gag and full-length conserved PERV, in blood cells collected periodically from organrecipient monkeys that underwent pig to non-human primate xenotransplantation. The heart and kidney?respectively acquired from α-1,3-galactosyltransferase knockout (GT-KO) pigs that survived for24 and 25 days?were xenografted into cynomolgus monkeys. The two PERV elements expressed in the xenografted GT-KO pig organs were not present in the blood cells of the recipient monkeys. In the present study, we deduced that PERVs are not transmitted during GT-KO pig to monkey xenotransplantation.
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References
참고문헌 (12)
참고문헌 신청
1. [학술지(정기간행물)] - van der Windt DJ. / 2012 / Clinical islet xenotransplantation : how close are we? / Diabetes 61 (12) : 3046 ~ 3055
2. [학술지(정기간행물)] - Dieckhoff B. / 2008 / Knockdown of porcine endogenous retrovirus(PERV)expression by PERV-specific shRNA in transgenic pigs / Xenotransplantation 15 (1) : 36 ~ 45
3. [학술지(정기간행물)] - 황성수 / 2012 / α1,3-Galactosyltransferase(GalT) 유전자가 완전 Knock-out(-/-)된 바이오장기용 형질 전환 돼지 생산 / 한국수정란이식학회지 27 (1) : 9 ~ 14
4. [학술지(정기간행물)] - Irgang M. / 2003 / Porcine endogenous retroviruses : no infection in patients treated with a bioreactor based on porcine liver cells / J ClinVirol 28 (2) : 141 ~ 154
5. [학술지(정기간행물)] - Karlas A. / 2010 / Characterisation of a human cell-adapted porcine endogenous retrovirus PERV-A/C / Ann Transplant 15 (2) : 45 ~ 54
2. [학술지(정기간행물)] - Dieckhoff B. / 2008 / Knockdown of porcine endogenous retrovirus(PERV)expression by PERV-specific shRNA in transgenic pigs / Xenotransplantation 15 (1) : 36 ~ 45
3. [학술지(정기간행물)] - 황성수 / 2012 / α1,3-Galactosyltransferase(GalT) 유전자가 완전 Knock-out(-/-)된 바이오장기용 형질 전환 돼지 생산 / 한국수정란이식학회지 27 (1) : 9 ~ 14
4. [학술지(정기간행물)] - Irgang M. / 2003 / Porcine endogenous retroviruses : no infection in patients treated with a bioreactor based on porcine liver cells / J ClinVirol 28 (2) : 141 ~ 154
5. [학술지(정기간행물)] - Karlas A. / 2010 / Characterisation of a human cell-adapted porcine endogenous retrovirus PERV-A/C / Ann Transplant 15 (2) : 45 ~ 54
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UCI(KEPA) : I410-ECN-0101-2015-500-001679245