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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.6
- 수록면
- 84 - 89 (6page)
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초록· 키워드
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The effects of an ethanolic extract of Angelica gigas (EAG) on the vascular smooth muscle cell (VSMC) proliferation and high-cholesterol diet-induced hypercholesterolemia and atherosclerosis were investigated. Rat aortic VSMCs were stimulated with platelet-derived growth factor-BB (25 ng/mL) for the induction of DNA synthesis and cell proliferation. EAG (1-10 μg/mL) significantly inhibited both the thymidine incorporation and cell proliferation in a concentration-dependent manner. Hypercholesterolemia was induced by feeding male New Zealand white rabbits with 0.5% cholesterol in diet for 10 weeks, during which EAG (1% in diet) was given for the final 8 weeks after 2-week induction of hypercholesterolemia. Hypercholesterolemic rabbits exhibited great increases in serum total cholesterol and low-density lipoproteins (LDL) levels, and finally severe atheromatous plaque formation covering 28.4% of the arterial walls. EAG significantly increased high-density lipoproteins (HDL), slightly decreased LDL, and potentially reduced the atheroma area to 16.6%. The results indicate that EAG attenuates atherosclerosis not only by inhibiting VASC proliferation, but also by increasing blood HDL levels. Therefore, it is suggested that EAG could be an alternative or an adjunct therapy for the improvement of hypercholesterolemia and atherosclerosis.
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References
참고문헌 (39)
참고문헌 신청
1. [학술지(정기간행물)] - Huh KB. / 1990 / The present status of nutrition-related diseases and its countermeasures / Kor J Nutr 23 (3) : 197 ~ 207
2. [학술지(정기간행물)] - Lee HK / 1996 / Pattern of disease incidence and nutrition in Korea / Kor J Nutr 29 (4) : 381 ~ 383
3. [학술지(정기간행물)] - Lee YC. / 1991 / Hypercholesterolemia in Korea and nutritional factors / Korean Soc Lipidol Atherosc 1 (1) : 111 ~ 122
4. [학술지(정기간행물)] - Spady DK. / 1993 / Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids / Annu Rev Nutr 13 : 355 ~ 381
5. [학술지(정기간행물)] - Natio HK. / 1995 / Atherogenesis : current topics on etiology and risk factors / Clin Chem 41 : 132 ~ 133
2. [학술지(정기간행물)] - Lee HK / 1996 / Pattern of disease incidence and nutrition in Korea / Kor J Nutr 29 (4) : 381 ~ 383
3. [학술지(정기간행물)] - Lee YC. / 1991 / Hypercholesterolemia in Korea and nutritional factors / Korean Soc Lipidol Atherosc 1 (1) : 111 ~ 122
4. [학술지(정기간행물)] - Spady DK. / 1993 / Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids / Annu Rev Nutr 13 : 355 ~ 381
5. [학술지(정기간행물)] - Natio HK. / 1995 / Atherogenesis : current topics on etiology and risk factors / Clin Chem 41 : 132 ~ 133
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