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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.6
- 수록면
- 64 - 72 (9page)
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This study was conducted to assess the feasibility of image guided radiotherapy (IGRT) for orthotopic 4T1 mouse mammary tumor using linear accelerator (LINAC). Eighteen Balb/C mice were inoculated with 4T1 cells on left mammary fat pad and nine of them were irradiated using LINAC. Tumors, planning target volumes (PTV), bowels adjacent to tumors, bones and lungs were delineated on planning CT images. IGRT plans were generated to irradiate prescription dose to at least 90% of the PTV and then compared with conventional 2-dimensional plans with anterior-posterior and posterior-anterior beams with 5 mm margins (2D AP/PA plan). Homemade dose-build-up-cradle was designed to encompass mouse bed for homogeneous dose build up. To confirm the irradiated dose, tumor doses were measured using diode detector placed on the surface of tumors. Plan comparison demonstrated equivalent doses to PTV while sparing more doses to normal tissues including bowel (from 90.9% to 40.5%, median value of mean doses) and bone marrow (from 12.9% to 4.7%, median value of mean doses) than 2D AP/PA plan. Quality assurance using diode detector confirmed that IGRT could deliver 95.3-105.3% of the planned doses to PTV. Tumors grew 505.2-1185.8% (mean 873.3%) in the control group and 436.1-771.8% (mean 615.5%) in the irradiated group. These results demonstrate that LINAC-based IGRT provides a reliable approach with accurate dose delivery in the radiobiological study for orthotropic tumor model maintaining tumor microenvironment.
목차
Materials and Methods
Results
Discussion
References
참고문헌 (17)
참고문헌 신청
1. [학술지(정기간행물)] - Fidler IJ. / 1994 / Modulation of tumor cell response to chemotherapy by the organ environment / Cancer Metastasis Rev 13 (2) : 209 ~ 222
2. [학술지(정기간행물)] - Kuo TH. / 1993 / Site-specific chemosensitivity of human small-cell lung carcinoma growing orthotopically compared to subcutaneously in SCID mice : the importance of orthotopic models to obtain relevant drug evaluation data / Anticancer Res 13 (3) : 627 ~ 630
3. [학술지(정기간행물)] - Demaria S. / 2005 / Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer / Clin Cancer Res 11 (2 Pt 1) : 728 ~ 734
4. [학술지(정기간행물)] - Pilones KA. / 2009 / Invariant natural killer T cells regulate breast cancer response to radiation and CTLA-4 blockade / Clin Cancer Res 15 (2) : 597 ~ 606
5. [학술지(정기간행물)] - Bouquet F. / 2011 / TGFâ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo / Clin Cancer Res 17 (21) : 6754 ~ 6765
2. [학술지(정기간행물)] - Kuo TH. / 1993 / Site-specific chemosensitivity of human small-cell lung carcinoma growing orthotopically compared to subcutaneously in SCID mice : the importance of orthotopic models to obtain relevant drug evaluation data / Anticancer Res 13 (3) : 627 ~ 630
3. [학술지(정기간행물)] - Demaria S. / 2005 / Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer / Clin Cancer Res 11 (2 Pt 1) : 728 ~ 734
4. [학술지(정기간행물)] - Pilones KA. / 2009 / Invariant natural killer T cells regulate breast cancer response to radiation and CTLA-4 blockade / Clin Cancer Res 15 (2) : 597 ~ 606
5. [학술지(정기간행물)] - Bouquet F. / 2011 / TGFâ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo / Clin Cancer Res 17 (21) : 6754 ~ 6765
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UCI(KEPA) : I410-ECN-0101-2015-500-001679205