지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.6
- 수록면
- 109 - 116 (8page)
이용수
초록· 키워드
오류제보하기
Glucosinolates (GLSs) are abundant in cruciferous vegetables and reported to have anti thyroidal effects. Four GLSs (sinigrin, progoitrin, glucoerucin, and glucotropaeolin) were administered orally to rats, and the breakdown products of GLSs (GLS-BPs: thiocyanate ions, cyanide ions, organic isothiocyanates, organic nitriles, and organic thiocyanates) were measured in serum. Thiocyanate ions were measured by colorimetric method, and cyanide ions were measured with CI-GC-MS. Organic isothiocyanates and their metabolites were measured with the cyclocondensation assay. Organic nitriles and organic thiocyanates were measured with EI-GC-MS. In all treatment groups except for progoitrin, thiocyanate ions were the highest among the five GLS-BPs. In the progoitrin treated group, a high concentration of organic isothiocyanates (goitrin) was detected. In the glucoerucin treated group, a relatively low amount of goitrogenic substances was observed. The metabolism to thiocyanate ions happened within five hours of the administration, and the distribution of GLSs varied with the side chain. GLSs with side chains that can form stable carbocation seemed to facilitate the degradation reaction and produce a large amount of goitrogenic thiocyanate ions. Because goitrogenic metabolites can be formed without myrosinase, the inactivation of myrosinase during cooking would have no effect on the anti-nutritional effect of GLSs in cruciferous vegetables.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
Fahey, J. W. / 2001 / The chemical diversity and distribution of glucosinolates and isothiocyanates among plants / Phytochemistry 56:5~51
Fenwick, G.R. / 1982 / Glucosinolates and their breakdown products in food and food plants / Crit. Rev. Food Sci. Nutr 18:123~201
Shapiro, T. A. / 2001 / Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts metabolism and excretion in humans / Cancer Epidemiol. Biomarkers Prev 10:501~508
Maskell, I. / 1994 / Degradation of glucosinolates during in vitro incubations of rapeseed meal with myrosinase (EC 3.2.3.1) and with pepsin (EC 3.4.23.1)-hydrochloric acid, and contents of porcine small intestine and caecum / Br. J. Nutr 72:455~466
Mennicke, W. / 1987 / Determination of N-acetyl-S-(N-alkylthiocarbamoyl)-L-cysteine, a principal metabolite of alkyl isothiocyanates, in rat urine / J. Chromatogr. B Biomed. Sci. Appl 414:19~24
Fenwick, G.R. / 1982 / Glucosinolates and their breakdown products in food and food plants / Crit. Rev. Food Sci. Nutr 18:123~201
Shapiro, T. A. / 2001 / Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts metabolism and excretion in humans / Cancer Epidemiol. Biomarkers Prev 10:501~508
Maskell, I. / 1994 / Degradation of glucosinolates during in vitro incubations of rapeseed meal with myrosinase (EC 3.2.3.1) and with pepsin (EC 3.4.23.1)-hydrochloric acid, and contents of porcine small intestine and caecum / Br. J. Nutr 72:455~466
Mennicke, W. / 1987 / Determination of N-acetyl-S-(N-alkylthiocarbamoyl)-L-cysteine, a principal metabolite of alkyl isothiocyanates, in rat urine / J. Chromatogr. B Biomed. Sci. Appl 414:19~24
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UCI(KEPA) : I410-ECN-0101-2015-510-001705037