지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.86 No.6
- 발행연도
- 2014.6
- 수록면
- 302 - 308 (7page)
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초록· 키워드
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Purpose: Prostaglandin E2 (PGE2) is a contributory carcinogen in gastric adenocarcinoma. 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) catabolizes PGE2 by oxidizing its 15(s)-hydroxy group. The aim of this study was to investigate the expression of 15-PGDH in gastric adenocarcinoma tissue and the relationship between 15-PGDH expression and clinicopathologic features of gastric adenocarcinoma.
Methods: Ninety-nine patients who underwent surgical resection for gastric adenocarcinoma between January 2007 and December 2007 were enrolled and evaluated retrospectively.
Results: In 62 patients (62.6%), 15-PGDH expression was lower in gastric adenocarcinoma tissue than in nonneoplastic tissue. Regarding the relationship between 15-PGDH expression and clinicopathological features, 15-PGDH expression was significantly lower in tissues with poor differentiation (P = 0.002), advanced T stage (P = 0.0319), a higher number of lymph node metastases (P = 0.045), lymphatic invasion (P = 0.031), and vascular invasion (P = 0.036).
Conclusion: 15-PGDH expression was associated with a subset of clinicopathologic features such as differentiation grade, T stage, lymphatic invasion, and vascular invasion.
Methods: Ninety-nine patients who underwent surgical resection for gastric adenocarcinoma between January 2007 and December 2007 were enrolled and evaluated retrospectively.
Results: In 62 patients (62.6%), 15-PGDH expression was lower in gastric adenocarcinoma tissue than in nonneoplastic tissue. Regarding the relationship between 15-PGDH expression and clinicopathological features, 15-PGDH expression was significantly lower in tissues with poor differentiation (P = 0.002), advanced T stage (P = 0.0319), a higher number of lymph node metastases (P = 0.045), lymphatic invasion (P = 0.031), and vascular invasion (P = 0.036).
Conclusion: 15-PGDH expression was associated with a subset of clinicopathologic features such as differentiation grade, T stage, lymphatic invasion, and vascular invasion.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Gupta RA. / 2001 / Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2 / Nat Rev Cancer 1 : 11 ~ 21
2. [학술지(정기간행물)] - Wang D. / 2006 / Prostaglandins and cancer / Gut 55 : 115 ~ 122
3. [학술지(정기간행물)] - Simmons DL. / 2004 / Cyclooxygenase isozymes : the biology of prostaglandin synthesis and inhibition / Pharmacol Rev 56 : 387 ~ 437
4. [학술지(정기간행물)] - Eisinger AL. / 2007 / The role of cyclooxygenase-2 and prostaglandins in colon cancer / Prostaglandins Other Lipid Mediat 82 : 147 ~ 154
5. [학술지(정기간행물)] - 남기택 / 2004 / The selective cyclooxygenase-2 inhibitor nimesulide prevents Helicobacter pylori-associated gastric cancer development in a mouse model / CLINICAL CANCER RESEARCH 10 (23) : 8105 ~ 8113
2. [학술지(정기간행물)] - Wang D. / 2006 / Prostaglandins and cancer / Gut 55 : 115 ~ 122
3. [학술지(정기간행물)] - Simmons DL. / 2004 / Cyclooxygenase isozymes : the biology of prostaglandin synthesis and inhibition / Pharmacol Rev 56 : 387 ~ 437
4. [학술지(정기간행물)] - Eisinger AL. / 2007 / The role of cyclooxygenase-2 and prostaglandins in colon cancer / Prostaglandins Other Lipid Mediat 82 : 147 ~ 154
5. [학술지(정기간행물)] - 남기택 / 2004 / The selective cyclooxygenase-2 inhibitor nimesulide prevents Helicobacter pylori-associated gastric cancer development in a mouse model / CLINICAL CANCER RESEARCH 10 (23) : 8105 ~ 8113
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