지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.4
- 수록면
- 63 - 67 (5page)
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초록· 키워드
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The present study was carried out to investigate the potential acute toxicity of new enzyme-treated royal jelly (RJ) by a single oral dose in Sprague Dawley (SD) rats. The sample was prepared by treating the RJ with four enzymes approved as food additives by the KFDA for improving digestion and absorption of nutrients. Male and female rats were randomly assigned to four groups of 10 rats each. The test articles were administered once by the gavage to rats at dose levels of 0 (placebo control), 1,250, 2,500 and 5,000mg/kg body weight. Mortalities, clinical findings, and body weight changes were monitored for 14 days after dosing. At the end of 14 day observation period, all animals were sacrificed, and the completed gross postmortem examinations were performed. There were no dead animals and specific adverse effects on clinical signs, the body weight, and the gross finding on males and females of the all groups, except for the transient clinical signs such as polyuria and diarrhea. Consequently, no toxic effect was observed at the dose levels of 1,250, 2,500, or 5,000mg/kg body weight in rats. The approximate lethal dose (ALD) of new enzyme-treated freeze dried (ETFD) RJ may be more than 5,000mg/kg body weight. Therefore, oral administration of ETFD RJ did not show any toxic effects to all rats upto 5,000mg, the highest dosage tested in this study and is likely to be safe in humans.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
LITERATURE CITED
참고문헌 (17)
참고문헌 신청
1. [단행본] - Cho, Y. / 2009 / Development of royal jelly as a functional dietary source for anti-aging and anti-oxidation of skin / Rural Development Administration
2. [학술지(정기간행물)] - Fujii, A. / 1990 / Augmentation of wound healing by royal jelly (RJ) in streptozotocin-diabetic rats / Jpn.J.Pharmacol 53 : 331 ~ 337
3. [학술지(정기간행물)] - Fukutomi, Y. / 2011 / Rhinoconjunctival sensitization to hydrolyzed wheat protein in facial soap can induce wheat-dependent exercise-induced anaphylaxis / J. Allergy Clin. Immunol 127 : 531 ~ 533
4. [보고서] - Korea food and drug administration. / 2009 / Testing guidelines for safety evaluation of drugs
5. [인터넷자원] - Krell, R. / / Value-added products from beekeeping /
2. [학술지(정기간행물)] - Fujii, A. / 1990 / Augmentation of wound healing by royal jelly (RJ) in streptozotocin-diabetic rats / Jpn.J.Pharmacol 53 : 331 ~ 337
3. [학술지(정기간행물)] - Fukutomi, Y. / 2011 / Rhinoconjunctival sensitization to hydrolyzed wheat protein in facial soap can induce wheat-dependent exercise-induced anaphylaxis / J. Allergy Clin. Immunol 127 : 531 ~ 533
4. [보고서] - Korea food and drug administration. / 2009 / Testing guidelines for safety evaluation of drugs
5. [인터넷자원] - Krell, R. / / Value-added products from beekeeping /
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