지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.3
- 수록면
- 28 - 36 (9page)
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초록· 키워드
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Objectives：The goal of this study was to examine the association between zinc and lead level and symptoms of attentiondeficit hyperactivity disorder (ADHD) among Korean children.
Methods：A total of 89 clinic-referred children participated in the study (ADHD group=45, control group=44). The participants were 5?15 years old, and were mainly from urban areas of Seoul, Korea. ADHD was diagnosed using the Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version. We excluded children with a comorbid psychiatric disorder, medical illness requiring medication, or a prior history of taking ADHD medication. In order to evaluate the severity of ADHD symptoms, parents’ Korean ADHD Rating Scale (K-ARS) was used. The ADHD diagnostic system (ADS) was used for evaluation of the severity of inattention and impulsivity. All participants completed the intelligence test and hair mineral analysis. Multiple regression analysis was used to examine the effect of hair zinc and lead levels on the K-ARS and ADS. We measured the predictive ability of the zinc and lead levels using logistic regression analysis.
Results：The lead level explained the score for omission errors, commission errors, and response time SD in visual ADS in the ADHD group (adjusted R²=.243, p<.01, adjusted R²=.362, p<.01, and adjusted R²=.275, p<.01), the score for omission errors of auditory ADS in ADHD group (adjusted R²=.407, p<.01) and the entire group (adjusted R²=.292, p<.01). Zinc was significantly explanatory for the K-ARS scores for the entire group (adjusted R²=.248, p<.001) and the ADHD group (adjusted R²=.247, p<.05).
Conclusion：These findings suggest a possible role of zinc and lead in ADHD. Lead concentration in hair samples affected the ADS scores, and this was more prominent in children with ADHD. Children with ADHD had a lower zinc concentration in their hair, and the zinc concentration in hair showed negative correlation with the K-ARS score.
Methods：A total of 89 clinic-referred children participated in the study (ADHD group=45, control group=44). The participants were 5?15 years old, and were mainly from urban areas of Seoul, Korea. ADHD was diagnosed using the Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version. We excluded children with a comorbid psychiatric disorder, medical illness requiring medication, or a prior history of taking ADHD medication. In order to evaluate the severity of ADHD symptoms, parents’ Korean ADHD Rating Scale (K-ARS) was used. The ADHD diagnostic system (ADS) was used for evaluation of the severity of inattention and impulsivity. All participants completed the intelligence test and hair mineral analysis. Multiple regression analysis was used to examine the effect of hair zinc and lead levels on the K-ARS and ADS. We measured the predictive ability of the zinc and lead levels using logistic regression analysis.
Results：The lead level explained the score for omission errors, commission errors, and response time SD in visual ADS in the ADHD group (adjusted R²=.243, p<.01, adjusted R²=.362, p<.01, and adjusted R²=.275, p<.01), the score for omission errors of auditory ADS in ADHD group (adjusted R²=.407, p<.01) and the entire group (adjusted R²=.292, p<.01). Zinc was significantly explanatory for the K-ARS scores for the entire group (adjusted R²=.248, p<.001) and the ADHD group (adjusted R²=.247, p<.05).
Conclusion：These findings suggest a possible role of zinc and lead in ADHD. Lead concentration in hair samples affected the ADS scores, and this was more prominent in children with ADHD. Children with ADHD had a lower zinc concentration in their hair, and the zinc concentration in hair showed negative correlation with the K-ARS score.
목차
Introduction
Methods
Results
Discussion
Conclusion
References
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Biederman J / 2005 / Attention-deficit hyperactivity disorder / Lancet 366 : 237 ~ 248
2. [학술지(정기간행물)] - Nigg JT. / 2008 / ADHD, lead exposure and prevention: how much lead or how much evidence is needed? / Expert Rev Neurother 8 : 519 ~ 521
3. [학술지(정기간행물)] - Bellinger DC. / 2011 / The protean toxicities of lead: new chapters in a familiar story / Int J Environ Res Public Health 8 : 2593 ~ 2628
4. [학술지(정기간행물)] - Jusko TA / 2008 / Blood lead concentrations < 10 microg/dL and child intelligence at 6 years of age / Environ Health Perspect 116 : 243 ~ 248
5. [학술지(정기간행물)] - Braun JM / 2006 / Exposures to environmental toxicants and attention deficit hyperactivity disorder in U.S. children / Environ Health Perspect 114 : 1904 ~ 1909
2. [학술지(정기간행물)] - Nigg JT. / 2008 / ADHD, lead exposure and prevention: how much lead or how much evidence is needed? / Expert Rev Neurother 8 : 519 ~ 521
3. [학술지(정기간행물)] - Bellinger DC. / 2011 / The protean toxicities of lead: new chapters in a familiar story / Int J Environ Res Public Health 8 : 2593 ~ 2628
4. [학술지(정기간행물)] - Jusko TA / 2008 / Blood lead concentrations < 10 microg/dL and child intelligence at 6 years of age / Environ Health Perspect 116 : 243 ~ 248
5. [학술지(정기간행물)] - Braun JM / 2006 / Exposures to environmental toxicants and attention deficit hyperactivity disorder in U.S. children / Environ Health Perspect 114 : 1904 ~ 1909
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UCI(KEPA) : I410-ECN-0101-2015-510-001314012