지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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To understand the effect of prenatal stress on sex-specific changes in embryonic and placental growth, a synthetic glucocorticoid (dexamethasone) was administered intraperitoneally at a dosage of 1 mg/kg body weight (BW) (Dex1) or 10 mg/kg BW (Dex10) to pregnant ICR mice at the gestational days 7.5, 8.5 and 9.5 post coitum (p.c.). Embryos and placentas were then harvested at days 11.5 and 18.5 p.c., and their body weight and size were measured following the determination of sex through PCR using Sry specific primers in tail tissues. As a result, female embryos presented reduced fetal body weight and size in Dex1- and Dex10-treated groups than those of control group at the embryonic day 11.5 p.c. Interestingly, the growth seems to be recovered at day 18.5 as there was no difference in growth between control and dexamethasone treated groups. In the case of males, Dex1 induced a decrease in fetal weight in day 11.5 and this pattern was maintained until day 18.5, whereas their growth was not affected by Dex10 treatment. Placental growth showed similar patterns to fetal growth in both sexes but the extent of reduction was not statistically significant in most cases. Placental weights in Dex1- and Dex10-treated group were decreased significantly in male only. The results imply that the effect of prenatal stress is largely sex dependent due to different strategies for growth and survival in a stressful environment.
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REFERENCES
참고문헌 (14)
참고문헌 신청
1. [학술지(정기간행물)] - Ain R / 2005 / Dexamethasone-induced intrauterine growth restriction impacts the placental prolactin family, insulin-like growth factor-II and the Akt signaling pathway / J Endocrinol 185 : 253 ~ 263
2. [학술지(정기간행물)] - Bale TL / 2011 / Sex differences in prenatal epigenetic programming of stress pathways / Stress 14 : 348 ~ 356
3. [학술지(정기간행물)] - Beversdorf DQ / 2005 / Timing of prenatal stressors and autism / J Autism Dev Disord 35 : 471 ~ 478
4. [학술지(정기간행물)] - Cottrell EC / 2009 / Prenatal stress, glucocorticoids and the programming of adult disease / Front Behav Neurosci 3 : 19 ~
5. [학술지(정기간행물)] - Cuffe JS / 2011 / Sex specific changes in placental growth and MAPK following short term maternal dexamethasone exposure in the mouse / Placenta 32 : 981 ~ 989
2. [학술지(정기간행물)] - Bale TL / 2011 / Sex differences in prenatal epigenetic programming of stress pathways / Stress 14 : 348 ~ 356
3. [학술지(정기간행물)] - Beversdorf DQ / 2005 / Timing of prenatal stressors and autism / J Autism Dev Disord 35 : 471 ~ 478
4. [학술지(정기간행물)] - Cottrell EC / 2009 / Prenatal stress, glucocorticoids and the programming of adult disease / Front Behav Neurosci 3 : 19 ~
5. [학술지(정기간행물)] - Cuffe JS / 2011 / Sex specific changes in placental growth and MAPK following short term maternal dexamethasone exposure in the mouse / Placenta 32 : 981 ~ 989
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UCI(KEPA) : I410-ECN-0101-2015-500-001321459