지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Occupational long-term exposure to inorganic dusts may cause a variety of lung diseases such as pneumoconiosis and chronic obstructive pulmonary disease (COPD). Diagnosis of pneumoconiosis and COPD, however, is currently dependent on radiological findings and pulmonary test, which are both late diagnostic tools. Therefore, there is a need to identify novel biomarkers in pneumoconiosis and COPD. Hence, in this current study we investigated the serum concentrations of YKL-40, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) as biomarkers for pneumoconiosis and COPD in 161 retired male workers exposed to inorganic dusts. The serum concentration of YKL-40 was significantly increased with age, pneumoconiosis, and airflow limitation. The serum concentration of IL-6 was significantly higher in airflow limitation. These results suggest that serum concentration of YKL-40 is associated with age, pneumoconiosis, and airflow limitation. Also, serum concentration of IL-6 is associated with airflow limitation.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (39)
참고문헌 신청
1. [학술지(정기간행물)] - Agustí AG / 2003 / Systemic effects of chronic obstructive pulmonary disease / Eur Respir J 21 : 347 ~ 360
2. [학술지(정기간행물)] - Barnes PJ / 2009 / Systemic manifestations and comorbidities of COPD / Eur Respir J 33 : 1165 ~ 1185
3. [학술지(정기간행물)] - Brøchner CB / 2012 / YKL-40 is differentially expressed in human embryonic stem cells and in cell progeny of the three germ layers / J Histochem Cytochem 60 : 188 ~ 204
4. [학술지(정기간행물)] - Brusasco V / 2005 / Series ATS/ERS Task Force: Standardisation of lung function testing / Eur Respir J 26 : 319 ~ 338
5. [학술지(정기간행물)] - Chupp GL / 2007 / A chitinaselike protein in the lung and circulation of patients with severe asthma / N Engl J Med 357 : 2016 ~ 2027
2. [학술지(정기간행물)] - Barnes PJ / 2009 / Systemic manifestations and comorbidities of COPD / Eur Respir J 33 : 1165 ~ 1185
3. [학술지(정기간행물)] - Brøchner CB / 2012 / YKL-40 is differentially expressed in human embryonic stem cells and in cell progeny of the three germ layers / J Histochem Cytochem 60 : 188 ~ 204
4. [학술지(정기간행물)] - Brusasco V / 2005 / Series ATS/ERS Task Force: Standardisation of lung function testing / Eur Respir J 26 : 319 ~ 338
5. [학술지(정기간행물)] - Chupp GL / 2007 / A chitinaselike protein in the lung and circulation of patients with severe asthma / N Engl J Med 357 : 2016 ~ 2027
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UCI(KEPA) : I410-ECN-0101-2015-500-001331402