지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.3
- 수록면
- 47 - 58 (12page)
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The effect of conjugated linoleic acid (CLA) isomers esterified in diacylglycerol (DAG)-rich oil on lipid metabolism was investigated. Since dietary DAG has been known to induce the regression of atherosclerosis, CLA-DAG and olive-DAG oils containing similar levels of DAG (51.4~54.2%) were synthesized from olive oil. Hyperlipidemic C57BL/6J mice were then fed high-fat high-cholesterol diets supplemented with these oils (5% each) for 7 wk. The CLA-DAG diet containing 2.1% CLA isomers (0.78% c9,t11-CLA; 1.18% t10,c12-CLA) remarkably increased the levels of total plasma cholesterol and glutamic oxaloacetic transaminase (GOT) along with hepatic cholesterol and triacylglycerol (TAG) contents. Furthermore, the CLA-DAG diet inhibited fat uptake into adipose tissue whereas fat deposition (especially in the liver) was increased, resulting in the development of fatty livers. Hepatic fatty acid composition in the CLA-DAG mice was different from that of the olive-DAG mice, showing higher ratios of C16:1/C16:0 and C18:1/C18:0 in the liver. The activity of hepatic acyl-CoA:cholesterol acyltransferase (ACAT) was higher in CLA-DAG mice while plasma lecithin:cholesterol acyltransferase (LCAT) activity and the ferric reducing ability of plasma (FRAP) were lower in CLA-DAG mice compared to the olive-DAG animals. Results of the present study suggest that CLA incorporation into DAG oil could induce atherosclerosis in mice.
목차
Abstract
I. Introduction
II. Materials and methods
III. Results and discussion
IV. Conclusions
References
참고문헌 (35)
참고문헌 신청
Ametaj BN / 2003 / Effect of sample preparation, length of time, and sample size on quantification of total lipids from bovine liver / Journal of Agricultural and Food Chemistry 51:2105~2110
Arbonés-Mainar JM / 2006 / Trans-10, cis-12-and cis-9, trans-11-conjugated linoleic acid isomers selectively modify HDL-apolipoprotein composition in apolipoprotein E knockout mice / Journal of Nutrition 136:353~359
Benzie IF / 1996 / The ferric reducing ability of plasma(FRAP)as a measure of antioxidant power : the FRAP assay / Analytical Biochemistry 239:70~76
Bierbachm H / 1983 / Triacylglycerol biosynthesis in human small intestinal mucosa Acyl-CoA : monoglyceride acyltransferase / Digestion 28:138~147
Chang TY / 1997 / Acyl-coenzyme A : cholesterol acyltransferase / Annual Review of Biochemistry 66:613~618
Arbonés-Mainar JM / 2006 / Trans-10, cis-12-and cis-9, trans-11-conjugated linoleic acid isomers selectively modify HDL-apolipoprotein composition in apolipoprotein E knockout mice / Journal of Nutrition 136:353~359
Benzie IF / 1996 / The ferric reducing ability of plasma(FRAP)as a measure of antioxidant power : the FRAP assay / Analytical Biochemistry 239:70~76
Bierbachm H / 1983 / Triacylglycerol biosynthesis in human small intestinal mucosa Acyl-CoA : monoglyceride acyltransferase / Digestion 28:138~147
Chang TY / 1997 / Acyl-coenzyme A : cholesterol acyltransferase / Annual Review of Biochemistry 66:613~618
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UCI(KEPA) : I410-ECN-0101-2015-400-001329250