지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.3
- 수록면
- 55 - 63 (9page)
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초록· 키워드
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Objectives: The use of indium compounds, especially those of small size, for the production of semiconductors, liquid-crystal panels, etc., has increased recently. However, the role of particle size or the chemical composition of indium compounds in their toxicity and distribution in the body has not been sufficiently investigated. Therefore, the aim of this study was to examine the effects of particle size and the chemical composition of indium compounds on their toxicity and distribution. Methods: Male Sprague-Dawley rats were exposed to two different-sized indium oxides (average particle sizes under 4,000 nm [IO_4000] and 100 nm [IO_100]) and one nano-sized indium-tin oxide (ITO; average particle size less than 50 nm) by inhalation for 6 hr daily, 5 days per week, for 4 weeks at approximately 1 mg/㎥ of indium by mass concentration. Results: We observed differences in lung weights and histopathological findings, differential cell counts, and cell damage indicators in the bronchoalveolar lavage fluid between the normal control group and IO- or ITO-exposed groups. However, only ITO affected respiratory functions in exposed rats. Overall, the toxicity of ITO was much higher than that of IOs; the toxicity of IO_4000 was higher than that of IO_100. A 4-week recovery period was not sufficient to alleviate the toxic effects of IO and ITO exposure. Inhaled indium was mainly deposited in the lungs. ITO in the lungs was removed more slowly than IOs; IO_4000 was removed faster than IO_100. IOs were not distributed to other organs (i.e., the brain, liver, and spleen), whereas ITO was. Concentrations of indium in the blood and organ tissues were higher at 4 weeks after exposure. Conclusions: The effect of particle size on the toxicity of indium compounds was not clear, whereas chemical composition clearly affected toxicity; ITO showed much higher toxicity than that of IO.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (27)
참고문헌 신청
Woon, Y. R. / 2012 / Pulmonary disorder with indium compounds
Leach, L. J. / 1961 / The inhalation toxicity of indium sesquioxide in the rat
American Conference of Governmental Industrial Hygienists / 1986 / Documentation of the threshold limit values and biological exposure indices / Cincinnati :101
Ministry of Employment and Labor / 2013 / The notification No. 2013-38 for exposure standard on chemical substances and physical properties issued on August 14 / MOEL
Ministry of Health Labour and Welfare / 2004 / The notification No. 0713001 for protecting workers exposure to indium-tin oxide and its related indium compounds issued on July 13, MHLW, Japan, No. 0713001 / MHLW
Leach, L. J. / 1961 / The inhalation toxicity of indium sesquioxide in the rat
American Conference of Governmental Industrial Hygienists / 1986 / Documentation of the threshold limit values and biological exposure indices / Cincinnati :101
Ministry of Employment and Labor / 2013 / The notification No. 2013-38 for exposure standard on chemical substances and physical properties issued on August 14 / MOEL
Ministry of Health Labour and Welfare / 2004 / The notification No. 0713001 for protecting workers exposure to indium-tin oxide and its related indium compounds issued on July 13, MHLW, Japan, No. 0713001 / MHLW
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UCI(KEPA) : I410-ECN-0101-2015-510-001344061