지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.3
- 수록면
- 19 - 25 (7page)
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초록· 키워드
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Licochalcone (LC), a major phenolic retrochalcone from licorice, has anti-inflammatory activity. This study investigated the effects of licochalcone A (LCA) and licochalcone E (LCE) on Liver X receptor-α (LXRα)-mediated lipogenic gene expression and the molecular mechanisms underlying those effects. LCA and LCE antagonized the ability of LXRα agonists (T0901317 or GW3965) to increase sterol regulatory element binding protein-1c (SREBP-1c) expression and thereby inhibited target gene expression (e.g., FAS and ACC) in HepG2 cells. Moreover, treatment with LCA and LCE impaired LXRα/RXRα-induced CYP7A1-LXRE-luciferase (CYP7A1) transactivation. The AMPK-Sirt1 signaling pathway is an important regulator of energy metabolism and, therefore, a potential therapeutic target for metabolic diseases, including hepatic steatosis. We found here that LCE increased AMPK phosphorylation and Sirt1 expression. We conclude that LC inhibits SREBP-1c-mediated hepatic lipogenesis via activation of the AMPK/Sirt1 signaling pathway.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (32)
참고문헌 신청
Jakobsson, T. / 2012 / Liver X receptor biology and pharmacology: new pathways, challenges and opportunities / Trends Pharmacol. Sci 33:394~404
Akiyama, T. E. / 2002 / Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux / Mol. Cell Biol 22:2607~2619
Schultz, J. R. / 2000 / Role of LXRs in control of lipogenesis / Genes Dev 14:2831~2838
Repa, J. J. / 2000 / Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta / Genes Dev 14:2819~2830
Ferré, P. / 2010 / Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c / Diabetes Obes. Metab 12(2):83~92
Akiyama, T. E. / 2002 / Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux / Mol. Cell Biol 22:2607~2619
Schultz, J. R. / 2000 / Role of LXRs in control of lipogenesis / Genes Dev 14:2831~2838
Repa, J. J. / 2000 / Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta / Genes Dev 14:2819~2830
Ferré, P. / 2010 / Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c / Diabetes Obes. Metab 12(2):83~92
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UCI(KEPA) : I410-ECN-0101-2015-510-001344001