지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.3
- 수록면
- 13 - 18 (6page)
이용수
초록· 키워드
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Electronic cigarettes (e-cigarettes) are becoming increasingly popular worldwide and their cellular effects warrant further evaluation. In this study, we investigated the effects of an e-cigarette cartridge solution on allergen related asthmatic airway inflammation (AI) and airway hyperresponsiveness (AHR), when it is delivered by intratracheal route in mice. Asthmatic AI and AHR were induced by systemic sensitization to ovalbumin (OVA) followed by intratracheal, intraperitoneal, and aerosol allergen challenges in BALB/c mice. The cartridge solution of e-cigarette (containing 16 mg/ml nicotine) was diluted 50 times and 100 ?l of the diluted solution was intratracheally instilled to OVA-sensitized (OVA-S) mice two times a week for 10 weeks. Long-term e-cigarette inhalation elicited no remarkable changes in the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase enzymes in serum, however, increased infiltration of inflammatory cells including eosinophils, into airways from blood, aggravated the asthmatic AI and AHR, and stimulated the production of cytokines such as interleukin (IL)-4, IL-5 and IL-13, and OVA-specific IgE production. Our data suggest that the inhalation of e-cigarette solutions can function as an important factor to exacerbate the allergy-induced asthma symptoms. Further studies are needed to address the effects of e-cigarette solutions on human health.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (27)
참고문헌 신청
Uryupin, A. B. / 2013 / Qualitative and quantitative compositions of fluids for electronic cigarettes / Pharm. Chem. J 46:687~692
Polosa, R. / 2011 / Effect of an electronic nicotine delivery device (e-Cigarette) on smoking reduction and cessation:a prospective 6-month pilot study / BMC Public Health 11:786
Ingebrathsen, B. J. / 2012 / Electronic cigarette aerosol particle size distribution measurements / Inhalation Toxicol 24:976~984
Kuschner, W. G. / 2011 / Electronic cigarettes and thirdhand tobacco smoke:two emerging health care challenges for the primary care provider / Int. J. Gen. Med 4:115~120
Sungkyu Lee / 2011 / Public Health Challenges of Electronic Cigarettes in South Korea / 예방의학회지 44(6):235~241
Polosa, R. / 2011 / Effect of an electronic nicotine delivery device (e-Cigarette) on smoking reduction and cessation:a prospective 6-month pilot study / BMC Public Health 11:786
Ingebrathsen, B. J. / 2012 / Electronic cigarette aerosol particle size distribution measurements / Inhalation Toxicol 24:976~984
Kuschner, W. G. / 2011 / Electronic cigarettes and thirdhand tobacco smoke:two emerging health care challenges for the primary care provider / Int. J. Gen. Med 4:115~120
Sungkyu Lee / 2011 / Public Health Challenges of Electronic Cigarettes in South Korea / 예방의학회지 44(6):235~241
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UCI(KEPA) : I410-ECN-0101-2015-510-001343993