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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.19 No.1
- 발행연도
- 2014.3
- 수록면
- 19 - 26 (8page)
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초록· 키워드
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Increased consumption of fresh vegetables that are high in polyphenols has been associated with a reduced risk of oxidative stress-induced disease. The present study aimed to evaluate the antioxidant effects of spinach in vitro and in vivo in hyperlipidemic rats. For measurement of in vitro antioxidant activity, spinach was subjected to hot water extraction (WE) or ethanol extraction (EE) and examined for total polyphenol content (TPC), oxygen radical absorbance capacity (ORAC), cellular antioxidant activity (CAA), and antigenotoxic activity. The in vivo antioxidant activity of spinach was assessed using blood and liver lipid profiles and antioxidant status in rats fed a high fat-cholesterol diet (HFCD) for 6 weeks. The TPC of WE and EE were shown as 1.5±0.0 and 0.5±0.0 ㎎ GAE/g, respectively. Increasing the concentration of the extracts resulted in increased ORAC value, CAA, and antigenotoxic activity for all extracts tested. HFCD-fed rats displayed hyperlipidemia and increased oxidative stress, as indicated by a significant rise in blood and liver lipid profiles, an increase in plasma conjugated diene concentration, an increase in liver thiobarbituric acid reactive substances (TBARS) level, and a significant decrease in manganese superoxide dismutase (Mn-SOD) activity compared with rats fed normal diet. However, administration of 5% spinach showed a beneficial effect in HFCD rats, as indicated by decreased liver TBARS level and DNA damage in leukocyte and increased plasma conjugated dienes and Mn-SOD activity. Thus, the antioxidant activity of spinach may be an effective way to ameliorate high fat and cholesterol diet-induced oxidative stress.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
CONCLUSIONS
REFERENCES
참고문헌 (42)
참고문헌 신청
1. [인터넷자원] - Korean Statistical Information Service / / Analysis on the actual conditions of deaths
2. [학술지(정기간행물)] - Chen X / 2008 / The pharmacological effect of polysaccharides from Lentinus edodes on the oxidative status and expression of VCAM-1mRNA of thoracic aorta endothelial cell in high-fat-diet rats / Carbohyd Polym 74 : 445 ~ 450
3. [학술지(정기간행물)] - Lieber CS / 2007 / The combination of S-adenosylmethionine and dilinoleoylphosphatidylcholine attenuates nonalcoholic steatohepatitis produced by a high-fat diet in rats / Nutr Res 27 : 565 ~ 573
4. [학술지(정기간행물)] - Ma M / 2009 / Effect of the Lycium barbarum polysaccharides administration on blood lipid metabolism and oxidative stress of mice fed high-fat diet in vivo / Food Chem 113 : 872 ~ 877
5. [학술지(정기간행물)] - Schreibelt G / 2007 / Therapeutic potential and biological role of endogenous antioxidant enzymes in multiple sclerosis pathology / Brain Res Rev 56 : 322 ~ 330
2. [학술지(정기간행물)] - Chen X / 2008 / The pharmacological effect of polysaccharides from Lentinus edodes on the oxidative status and expression of VCAM-1mRNA of thoracic aorta endothelial cell in high-fat-diet rats / Carbohyd Polym 74 : 445 ~ 450
3. [학술지(정기간행물)] - Lieber CS / 2007 / The combination of S-adenosylmethionine and dilinoleoylphosphatidylcholine attenuates nonalcoholic steatohepatitis produced by a high-fat diet in rats / Nutr Res 27 : 565 ~ 573
4. [학술지(정기간행물)] - Ma M / 2009 / Effect of the Lycium barbarum polysaccharides administration on blood lipid metabolism and oxidative stress of mice fed high-fat diet in vivo / Food Chem 113 : 872 ~ 877
5. [학술지(정기간행물)] - Schreibelt G / 2007 / Therapeutic potential and biological role of endogenous antioxidant enzymes in multiple sclerosis pathology / Brain Res Rev 56 : 322 ~ 330
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UCI(KEPA) : I410-ECN-0101-2015-510-001352338