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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.3
- 수록면
- 21 - 27 (7page)
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The inhibitory effects of perilla oil on the platelet aggregation in vitro and thrombosis in vivo were investigated in comparison with aspirin, a well-known blood flow enhancer. Rabbit platelet-rich plasma was incubated with perilla oil and aggregation inducers collagen or thrombin, and the platelet aggregation rate was analyzed. Perilla oil significantly inhibited both the collagen- and thrombin-induced platelet aggregations, in which the thromboxane B₂ formation from collagen-activated platelets were reduced in a concentration-dependent manner. Rats were administered once daily by gavage with perilla oil for 1 week, carotid arterial thrombosis was induced by applying 35% FeCl₃-soaked filter paper for 10 min, and the blood flow was monitored with a laser Doppler probe. Perilla oil delayed the FeCl₃-induced arterial occlusion in a dose-dependent manner, doubling the occlusion time at 0.5 mL/kg. In addition, a high dose (2 mL/kg) of perilla oil greatly prevented the occlusion, comparable to the effect of aspirin (30 mg/kg). The results indicate that perilla oil inhibit platelet aggregation by blocking thromboxane formation, and thereby delay thrombosis following oxidative arterial wall injury. Therefore, it is proposed that perilla oil could be a good candidate without adverse effects for the improvement of blood flow.
목차
Materials and Methods
Results
Discussion
References
참고문헌 (34)
참고문헌 신청
1. [학술지(정기간행물)] - Majid A. / 2001 / Antiplatelet agents for secondary prevention of ischemic stroke / Ann Pharmacother 35 (10) : 1241 ~ 1247
2. [학술지(정기간행물)] - Jackson SP. / 2003 / Signaling events underlying thrombus formation / J Thromb Haemost 1 (7) : 1602 ~ 1612
3. [학술지(정기간행물)] - Farndale RW. / 2004 / The role of collagen in thrombosis and hemostasis / J Thromb Haemost 2 (4) : 561 ~ 573
4. [학술지(정기간행물)] - Konno C. / 1977 / Morusinol, isoprenoid flavone from Morus root barks / Planta Med 32 (2) : 118 ~ 124
5. [학술지(정기간행물)] - Cowan DH. / 1981 / Platelet adherence to collagen : role of prostaglandinthromboxane synthesis / Br J Haematol 49 (3) : 425 ~ 434
2. [학술지(정기간행물)] - Jackson SP. / 2003 / Signaling events underlying thrombus formation / J Thromb Haemost 1 (7) : 1602 ~ 1612
3. [학술지(정기간행물)] - Farndale RW. / 2004 / The role of collagen in thrombosis and hemostasis / J Thromb Haemost 2 (4) : 561 ~ 573
4. [학술지(정기간행물)] - Konno C. / 1977 / Morusinol, isoprenoid flavone from Morus root barks / Planta Med 32 (2) : 118 ~ 124
5. [학술지(정기간행물)] - Cowan DH. / 1981 / Platelet adherence to collagen : role of prostaglandinthromboxane synthesis / Br J Haematol 49 (3) : 425 ~ 434
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UCI(KEPA) : I410-ECN-0101-2015-500-001364432