지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 338 - 343 (6page)
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초록· 키워드
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Serum levels of alkaline phosphatase (ALP) are widely used in the clinical diagnosis of hepatic diseases and the assessment of liver status. They also have epidemiological significance to be prospective risk factors for bone diseases, such as osteitis deformans, rickets, osteomalacia, hyperparathyroidism, healing fractures, and osteoblastic bone tumors. In the previous study, single nucleotide polymorphisms (SNPs) in several genes have been reported to be associated with serum levels of liver enzyme in American population. We aimed to confirm whether the genetic variation of RETNLB (resistin like beta) gene also influence the serum levels of liver enzyme in Korean population. We genotyped variants in or near RETNLB in a population-based sample including 994 Korean adults. Here, we performed association analysis to elucidate the possible relations of genetic polymorphisms in RETNLB gene with serum levels of liver enzyme. By examining genotype data of a total of 944 subjects in 5 hospital health promotion centers, we discovered the RETNLB gene polymorphisms are associated with serum levels of ALP. The common and highest significant polymorphism was rs736327 (β=8.66, P=2.37E-05), rs7639070 (β=8.56, P=3.24E-05) with ALP in all groups. Furthermore, the ALP was consistently associated with rs736327 (β=10.40, P=5.23E-05), rs7639070 (β=10.32, P=6.74E-05) in the male population. Consequently, we found statistically significant SNPs in RETNLB gene that are associated with serum levels of ALP. In addition, these results suggest that the individuals with the minor alleles of the SNP in the RETNLB gene may have elevated serum levels of ALP in the Korean population.
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재료 및 방법
결과
고찰
REFERENCES
참고문헌 (10)
참고문헌 신청
1. [단행본] - Abraham NZ / 2007 / Clinical enzymology, In Henry's clinical diagnosis and management by laboratory methods / Elsevier Saunders : 245 ~ 262
2. [학술지(정기간행물)] - 안효준 / 2013 / Association between SMAD2 Gene and Serum Liver Enzyme Levels in the Korean Population / 대한의생명과학회지 19 (2) : 124 ~ 131
3. [단행본] - Burtis CA / 2006 / Tietz textbook of clinical chemistry and molecular diagnositcs / Elsevier Saunders : 191 ~ 218
4. [학술지(정기간행물)] - Cereghini S / 1990 / Hepatocyte dedifferentiation and extinction is accompanied by a block in the synthesis of mRNA coding for the transcription factor HNF1/LFB1 / EMBO J 9 : 2257 ~ 2263
5. [학술지(정기간행물)] - Christenson RH / 1997 / Biochemical markers of bone metabolism: an overview / Clin Biochem 30 : 573 ~ 593
2. [학술지(정기간행물)] - 안효준 / 2013 / Association between SMAD2 Gene and Serum Liver Enzyme Levels in the Korean Population / 대한의생명과학회지 19 (2) : 124 ~ 131
3. [단행본] - Burtis CA / 2006 / Tietz textbook of clinical chemistry and molecular diagnositcs / Elsevier Saunders : 191 ~ 218
4. [학술지(정기간행물)] - Cereghini S / 1990 / Hepatocyte dedifferentiation and extinction is accompanied by a block in the synthesis of mRNA coding for the transcription factor HNF1/LFB1 / EMBO J 9 : 2257 ~ 2263
5. [학술지(정기간행물)] - Christenson RH / 1997 / Biochemical markers of bone metabolism: an overview / Clin Biochem 30 : 573 ~ 593
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