지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.4
- 수록면
- 225 - 232 (8page)
- DOI
- 10.15188/kjopp.2013.04.27.2.225
이용수
초록· 키워드
오류제보하기
Delayed gastrointestinal (GI) motility is frequent adverse effect associated with chemotherapy, and induced by serotonin releases from enterochromaffin cells. Ijintang-gamibang (IJG) is a digestive polyherbal formula has been traditionally used in Korea and consisted of 8 types of medicinal herbs. This study was conducted to determine whether or not IJG aqueous extracts can prevent delayed GI motility induced by the antineoplastic drug cisplatin chronically administered, once per week for five consecutive weeks (2 mg/kg). 200, 100 and 50 mg/kg of IJG extracts were orally administered, once a day for 14 days from fourth cisplatin treatment, and the changes in body weight gain, fecal parameters, gastrointestinal transit ratio and histopathology were observed. In addition, pylorus gastrin and serotonin contents were also measured with immunohistochemical observations of enterochromaffin cells contains gastrin and serotonin, as compared with ondansetron, a serotonin 5-HT3 receptor antagonist, 1 mg/kg. Cisplatin treatment related body weight decreases, delayed GI motility, decreases of fecal water contents were significantly and dose-dependently inhibited by oral treatment of IJG extracts, and they also inhibited the pylorus gastrin and serotonin changes induced by cisplatin treatment. The overall effects of IJG 100 mg/kg were similar to that of ondansetron 1 mg/kg. The present results supported that IJG aqueous extracts have favorable ameliorating effect on the delayed GI motility induced by chemotheraphy, modulated the GI enterochromaffin cells, serotonin and gastrin-producing cells with antioxidant effects. This effect of IJG may help improve accompanying gastrointestinal symptoms by chemotherapy.
목차
서론
재료 및 방법
결과
고찰
결론
참고문헌
참고문헌 (39)
참고문헌 신청
1. [학술지(정기간행물)] - Visnovsky, P. / 1992 / The effect of cyclophosphamide and methotrexate on gastric emptying and secretion in rats / Bratisl Lek Listy 93 (2) : 90 ~ 82
2. [학술지(정기간행물)] - Yoshida, N. / 1992 / T. DAT-582, a novel serotonin3 receptor antagonist, is a potent and long-lasting antiemetic agent in the ferret and dog / J Pharmacol Exp Ther 260 (3) : 1159 ~ 1165
3. [학술지(정기간행물)] - Kishibayashi, N. / 1993 / Pharmacological properties of KF18259, a novel 5-HT3-receptor antagonist, in rats : inhibition of the distal colonic function / Jpn J Pharmacol 63 (4) : 495 ~ 502
4. [학술지(정기간행물)] - Lebwohl, D. / 1998 / Clinical development of platinum complexes in cancer therapy: an historical perspective and an update / Eur J Cancer 34 (10) : 1522 ~ 1534
5. [학술지(정기간행물)] - Sassi, G. / 2005 / A reporting system for the assessment of chemotherapy toxicity / J Oncol Pharm Pract 11 (2) : 63 ~ 67
2. [학술지(정기간행물)] - Yoshida, N. / 1992 / T. DAT-582, a novel serotonin3 receptor antagonist, is a potent and long-lasting antiemetic agent in the ferret and dog / J Pharmacol Exp Ther 260 (3) : 1159 ~ 1165
3. [학술지(정기간행물)] - Kishibayashi, N. / 1993 / Pharmacological properties of KF18259, a novel 5-HT3-receptor antagonist, in rats : inhibition of the distal colonic function / Jpn J Pharmacol 63 (4) : 495 ~ 502
4. [학술지(정기간행물)] - Lebwohl, D. / 1998 / Clinical development of platinum complexes in cancer therapy: an historical perspective and an update / Eur J Cancer 34 (10) : 1522 ~ 1534
5. [학술지(정기간행물)] - Sassi, G. / 2005 / A reporting system for the assessment of chemotherapy toxicity / J Oncol Pharm Pract 11 (2) : 63 ~ 67
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