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자료유형
학술저널
저자정보
공상은 (대전대학교) 오민석 (대전대학교)
저널정보
한의병리학회 동의생리병리학회지 동의생리병리학회지 제27권 제2호
발행연도
2013.4
수록면
212 - 224 (13page)
DOI
10.15188/kjopp.2013.04.27.2.212

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This study intends to clarify how Sayeok-tang(here in after reffered to SYT) affect C57BL/10 mice whose osteoarthritis was induced by papain. Osteoarthritis was induced by injecting papain in the knee joint of 3 groups(n=6) of mice. Normal group was non-treatment group and was not injected papain, whereas control mice were orally administered with 200 ㎕ of physiological saline. Positive comparison group was medicated with 100 mg/kg of Joins<SUP>®</SUP> mixed with 200 ㎕ of physiological saline. Experimental group was medicated with 400 mg/kg of SYT mixed with 200 ㎕ of physiological saline. Both Positive and experimental comparison groups were orally medicated once per day for 4 weeks. After the experiment, the functions of liver and kidney, inflammation cytokine values within serum, degree of revelation for inflammation cytokine genes, immune cells within blood, metabolism of arachidonic acid and amount of cartilage were measured and histopathological changes in the knee joint structures were observed. As results, SYT had no significant effect on the liver and kidney functions. Interleukin-1β(IL-1β), interleukin-6(IL-6), monocyte chemo attractant protein-1(MCP-1) and tumor necrosis factor-α(TNF-α) were significantly decreased. Inflammation cytokines in joints were all significantly decreased. Prostaglandin E₂(PGE₂), thromboxane B₂(TXB₂) were significantly decreased. Destruction of cartilage on micro computed tomography(CT)-arthrography was meaningfully decreased. In terms of histopathology, infiltration of inflammation, proliferation of synovial membrane, subsidence of cartilage and bone due to penetration of excessive formation of synovial cell and destruction of cartilage were small. Based on all results mentioned above, Sayeok-tang(SYT) is believed to be meaningful for suppressing the progress of osteoarthritis and its treatments because of its anti-inflammatory effects and alleviation of pain with histopathological effective efficacy.

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