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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.10
- 수록면
- 611 - 616 (6page)
- DOI
- 10.15188/kjopp.2013.10.27.5.611
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초록· 키워드
오류제보하기
Alcoholic liver disease (ALD) is a major cause of morbidity and mortality around the world. Although much progress has been made in understanding the pathogenesis of ALD, there remains no effective therapy for it. Accumulated evidence indicates that oxidative stress is the main pathological factors in the development of ALD. Ethanol administration causes accumulation of reactive oxygen species (ROS), including superoxide, hydroxyl radical, and hydrogen peroxide. ROS, in turn, cause lipid peroxidation of cellular membranes, and protein and DNA oxidation, which results in hepatocyte injury. In addition to pro-oxidants formation, antioxidants depletion caused by ethanol administration also results in oxidative stress. The objective of this study is to investigate the effects of Shiryung-tang extract on the chronic alcoholic liver injury induced by EtOH. Male Sprague Dawley rats were used in this study. All rats were maintained under standard laboratory conditions (23±1℃, 12h light/12h dark cycles). All animals (n=30) were randomly divided into following groups: (1) Normal group, treated with distilled water (n=10); (2) Control group, treated with ethanol (n=10); (3) Sample group, treated with ethanol + pharmacopuncture (n=10). For oral administration of ethanol in Control and Sample group, the ethanol was dissolved in distilled water in concentrations of 25%(v/v). Throughout the experiment of 8 week, the rats were allowed free access to water and standard chow. Sample group were administrated by Shiryung-tang extract daily for 8 weeks. Control group were given normal saline for same weeks. As a results, the oral administration of ethanol for 8 weeks leads to hepatotoxicity. The levels of hepatic marker such as HDL-cholesterol, triglyceride, aspartate aminotransferase and alanine aminotransferase were altered. The ethanol also increased lipid peroxidation and depletion of antioxidant enzyme activities as well as hepatic tissue injury. However, the treatment of Shiryung-tang extract prevented all the alterations induced by ethanol and returned their levels to near normal. These data suggest that Shiryung-tang extract could have a beneficial effect in inhibiting the oxidative damage induced by chronic ethanol administration. Therefore, Shiryung-tang extract can be a candidate to protect against EtOH-induced liver injury.
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서론
재료 및 방법
결과
고찰
결론
참고문헌
참고문헌 (31)
참고문헌 신청
1. [학술지(정기간행물)] - Crawford, J.M. / 2012 / Histologic findings in alcoholic liver disease / Clin Liver Dis 16 (4) : 699 ~ 716
2. [학술지(정기간행물)] - Casey, C. A. / 2001 / Alcoholic liver disease and apoptosis / Alcohol Clin Exp Res 25 (5) : 49 ~ 53
3. [학술지(정기간행물)] - Younossi, Z.M. / 2008 / Review article: current management of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis / Aliment Pharmacol Ther 28 (1) : 2 ~ 12
4. [학술지(정기간행물)] - Albano, E. / 2006 / Alcohol, oxidative stress and free radical damage / Proc Nutr Soc 65 (3) : 278 ~ 290
5. [학술지(정기간행물)] - Dey, A. / 2006 / Alcohol and oxidative liver injury / Hepatology 43 (2) : 63 ~ 74
2. [학술지(정기간행물)] - Casey, C. A. / 2001 / Alcoholic liver disease and apoptosis / Alcohol Clin Exp Res 25 (5) : 49 ~ 53
3. [학술지(정기간행물)] - Younossi, Z.M. / 2008 / Review article: current management of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis / Aliment Pharmacol Ther 28 (1) : 2 ~ 12
4. [학술지(정기간행물)] - Albano, E. / 2006 / Alcohol, oxidative stress and free radical damage / Proc Nutr Soc 65 (3) : 278 ~ 290
5. [학술지(정기간행물)] - Dey, A. / 2006 / Alcohol and oxidative liver injury / Hepatology 43 (2) : 63 ~ 74
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