지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
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Sulfuretin is one of the main flavonoids produced by Rhusverniciflua. Sulfuretin has been shown to exhibit many pharmacological activities including anti-oxidant, anti-obesity, anti-inflammatory and anti-mutagenic activities. However, the anti-skin photoaging effects of sulfuretin has not yet been reported. In the present study, we investigated the inhibitory effect of sulfuretin on the expression levels of MMP-1 and -3 in the human dermal fibroblast cells. Western blot analysis and real-time PCR revealed sulfuretin inhibited UVB-induced MMP-1 and -3 expressions in a dose-dependent manner. UVB-induced MAPK/NF-κB/p50 activation and MMP expression were completely blocked by pretreatment of sulfuretin. Taken together, sulfuretin could prevent UVB-induced MMP expressions through inhibition of MAPK/NF-κB/p50 activation.
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (38)
참고문헌 신청
Ho, J.N. / 2005 / Protective effects of aucubin isolated from Eucommia ulmoides against UVB-induced oxidative stress in human skin fibroblasts / BIOLOGICAL & PHARMACEUTICAL BULLETIN 28:1244~1248
Scharffetter-Kochanek, K / 2000 / Photoaging of the skin from phenotype to mechanisms / Exp Gerontol 35:307~316
Jackson, C / 2001 / Selective matrix metalloproteinase (MMP) inhibition in rheumatoid arthritis--targetting gelatinase A activation / Inflamm Res 50:183~186
Brenneisen, P. / 2002 / Ultraviolet-B irradi-ation and matrix metalloproteinases: from induction via signaling to initial events / Ann N Y Acad Sci 973:31~43
Brenneisen, P. / 2000 / Activation of p70 ribosomal protein S6 kinase is an essential step in the DNA damage-dependent signaling pathway responsible for the ultraviolet B-mediated increase in interstitial collagenase (MMP-1) and stromelysin-1 (MMP-3) protein levels in human dermal fibroblasts / J Biol Chem 275:4336~4344
Scharffetter-Kochanek, K / 2000 / Photoaging of the skin from phenotype to mechanisms / Exp Gerontol 35:307~316
Jackson, C / 2001 / Selective matrix metalloproteinase (MMP) inhibition in rheumatoid arthritis--targetting gelatinase A activation / Inflamm Res 50:183~186
Brenneisen, P. / 2002 / Ultraviolet-B irradi-ation and matrix metalloproteinases: from induction via signaling to initial events / Ann N Y Acad Sci 973:31~43
Brenneisen, P. / 2000 / Activation of p70 ribosomal protein S6 kinase is an essential step in the DNA damage-dependent signaling pathway responsible for the ultraviolet B-mediated increase in interstitial collagenase (MMP-1) and stromelysin-1 (MMP-3) protein levels in human dermal fibroblasts / J Biol Chem 275:4336~4344
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