지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Socheongryong-tang has been used for the treatment of inflammatory allergic diseases such as allergic rhinitis and bronchial asthma in Asian countries. This study was conducted to investigate the safety of Socheongryong-tang in rats. The safety of this tang on acute toxicity was evaluated by single dose toxicity study. Rats were orally administrated in a single dose of 0 and 2000 mg/kg (limited dose) Socheongryong-tang. There were 7 rats in each groups. All animals were sacrificed after 14 days of treatment. After single administration, mortality, clinlcal signs, body weight changes and gross pathological findings were observed for 14 days. Three parameters were tested: organ weight measurement, clinical chemistry, and hematology. In this study with rats, Socheongryong-tang treatment did not show any acute toxicity. No mortality was noted for 14 days of treatment. There were no adverse effects on clinical signs, body weight, organ weight and gross pathological findings at all treatment groups. The clinical chemistry parameters attesting to liver and kidney functions as well as the hematological parameters were within the normal ranges. From single dose toxicity study with rats, it is considered that LD50 of Socheongryong-tang is over 2000 mg/kg in oral administration. This finding of the safety on single dose toxicity study of Socheongryong-tang are expected to strengthen the position of Socheongryong-tang as nontoxic medicine.
목차
서론
재료 및 방법
결과
고찰
결론
참고문헌
참고문헌 (20)
참고문헌 신청
Ko, E.J. / 2004 / So-Cheong-Ryong-Tang, traditional Korean medicine, suppresses Th2 lineage development / Biol Pharm Bull 27(5):739~743
Ko, E.J. / 2004 / Traditional Korean medicine (SCRT) modulate Th1/Th2 specific cytokine production in mice CD4+ T cell / J Ethnopharmacol 91:121~128
동의학연구소 / 2006 / 새로보는 방약합편 / 도서출판 단샘 :236~252
허 준 / 2009 / 신대역 동의보감 / 법인문화사 :1091
Nakao, M. / 2007 / The effect of Shoseiryuto, a traditional Japanese medicine, on cytochrome P450s, N-acetyltransferase 2 and xanthine oxidase, in extensive or intermediate metabolizers of CYP2D6 / Eur J Clin Pharmacol 63:345~353
Ko, E.J. / 2004 / Traditional Korean medicine (SCRT) modulate Th1/Th2 specific cytokine production in mice CD4+ T cell / J Ethnopharmacol 91:121~128
동의학연구소 / 2006 / 새로보는 방약합편 / 도서출판 단샘 :236~252
허 준 / 2009 / 신대역 동의보감 / 법인문화사 :1091
Nakao, M. / 2007 / The effect of Shoseiryuto, a traditional Japanese medicine, on cytochrome P450s, N-acetyltransferase 2 and xanthine oxidase, in extensive or intermediate metabolizers of CYP2D6 / Eur J Clin Pharmacol 63:345~353
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0