지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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The stems and branchs of Euryale ferox Salisbury (EF), are used in Chinese herbal medicine for latent-heat-clearing, antipyretic, detoxicant and anti-inflammatory ailments. This plant is used worldwide for the treatment of many types of inflammatory disease including respiratory infections, diabetes mellitus, rheumatoid arthritis and play an important role in the immune reaction. Topical natural antioxidants are a useful strategy for the prevention of oxidative stress mediated inflammatory disease. Plants produce significant amounts of antioxidants to prevent the oxidative stress caused by photons and oxygen, therefore they represent a potential source of new compounds with antioxidant activity. This study was designed to evaluate whether EFEA (ethylacetate fraction of EF) may ameliorate oxidative stress and inflammatory status through the antioxidative mechanism in LPS-stimulated RAW 264.7 murine macrophage cell line. Treatment of RAW 264.7 cells with EFEA significantly reduced LPS-stimulated inflammatory response in a dose-dependent manner. In conclusion, the EF extracts have anti-inflammatory effects in vitro system, which can be used for developing pharmaceutical drug against oxidative stress and chronic inflammatory disease.
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참고문헌 (40)
참고문헌 신청
1. [학술지(정기간행물)] - Freeman, B.A / 1982 / Biology of disease: Free radicals and tissue injury / a Journal of Technical Methods and Pathology 47 : 412 ~ 426
2. [학술지(정기간행물)] - Sies, H / 1991 / Oxidative stress: from basic research to clinical application / Am. J. Med 30 : 31 ~ 38S
3. [학술지(정기간행물)] - Finkel, T. / 2000 / Oxidants, oxidative stress and the biology of ageing / Nature 408 (6809) : 239 ~ 247
4. [학술지(정기간행물)] - Azard, N / 2008 / Inflammationand lung cancer: roles of reactive oxygen/nitrogen species / J Toxicol Environ Health B Crit Rev 11 (1) : 11 ~ 15
5. [학술지(정기간행물)] - Halliwell, B / 1984 / Oxygen toxicity, oxygen radicals, transition metals and disease / Biochem. J 219 : 1 ~ 14
2. [학술지(정기간행물)] - Sies, H / 1991 / Oxidative stress: from basic research to clinical application / Am. J. Med 30 : 31 ~ 38S
3. [학술지(정기간행물)] - Finkel, T. / 2000 / Oxidants, oxidative stress and the biology of ageing / Nature 408 (6809) : 239 ~ 247
4. [학술지(정기간행물)] - Azard, N / 2008 / Inflammationand lung cancer: roles of reactive oxygen/nitrogen species / J Toxicol Environ Health B Crit Rev 11 (1) : 11 ~ 15
5. [학술지(정기간행물)] - Halliwell, B / 1984 / Oxygen toxicity, oxygen radicals, transition metals and disease / Biochem. J 219 : 1 ~ 14
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