지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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This study was conducted to determine the analgesic effect of Sokyungwhalhyul-tang(SKWHT) using the model of peripheral neuropathic pain model. A model of neuropathic pain was made by ligating left 5th lumbar spinal nerve of rats. After 1 days, the extract of SKWHT was orally administered daily. Rats were divided into four groups; (1) Control group(n=6), (2) Experimental group Ⅰ(SKWHT-OA1, 100 ㎎/㎏, n=6), (3) Experimental group Ⅱ(SKWHT-OA2, 300 ㎎/㎏, n=6), (4) Experimental group Ⅲ(SKWHT-OA3, 500 ㎎/㎏, n=6). After that, we examined the withdrawl response of neuropathic rats legs by von Frey filament and Hot plate at pre, 1<SUP>th</SUP>, 4<SUP>th</SUP>, 7<SUP>th</SUP>, 14<SUP>th</SUP>, 21<SUP>th</SUP> days after the induction of neuropathic pain. And also we examined c-fos, GOT, GPT and histological study of Liver at 21<SUP>th</SUP> days. von Frey filament and Hot plate were increase in experimental group Ⅰ,Ⅱ,Ⅲ than Con. especially group Ⅲ was most significantly analgesic effect than the other groups at 14<SUP>th</SUP>, 21<SUP>th</SUP> days. In c-fos protein expression on spinal cord, group Ⅲ was most significantly reduction immunoreactivity at 21<SUP>th</SUP> days and in blood serum GOT & GPT levels and histologic finding of Liver in all experimental groups were no significant difference with Con at 21<SUP>th</SUP> days. According to the above results, SKWHT(500 ㎎/㎏) may have a significant analgesic effect on the neuropathic pain.
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참고문헌
참고문헌 (37)
참고문헌 신청
1. [단행본] - Mitchell, S.W / 1872 / Injuries of nerves and their consequences / Lippincott : 252 ~
2. [단행본] - Bonica, J.J / 1990 / Causalgia and other reflex sympathetic dystrophies, In The Management of Pain / Lea and Febiger : 220 ~ 243
3. [학술지(정기간행물)] - Verdugo, R.J. / 1993 / Use and misuse of conventional electrodiagnosis, quantitative sensory testing, thermography, and nerve blocks in the evaluation of painful neuropathic syndromes / Muscle Nerve 16 : 1056 ~ 1082
4. [학술지(정기간행물)] - Bowsher, D / 1993 / Pain syndromes and their treatment / Curr Opin Neurol Neurosurg 6 : 257 ~ 263
5. [학술지(정기간행물)] - 郭靄春 / 1993 / 黃帝內經素問校注譯釋 / 醫聖堂 : 346 ~ 369
2. [단행본] - Bonica, J.J / 1990 / Causalgia and other reflex sympathetic dystrophies, In The Management of Pain / Lea and Febiger : 220 ~ 243
3. [학술지(정기간행물)] - Verdugo, R.J. / 1993 / Use and misuse of conventional electrodiagnosis, quantitative sensory testing, thermography, and nerve blocks in the evaluation of painful neuropathic syndromes / Muscle Nerve 16 : 1056 ~ 1082
4. [학술지(정기간행물)] - Bowsher, D / 1993 / Pain syndromes and their treatment / Curr Opin Neurol Neurosurg 6 : 257 ~ 263
5. [학술지(정기간행물)] - 郭靄春 / 1993 / 黃帝內經素問校注譯釋 / 醫聖堂 : 346 ~ 369
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