지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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The object of this study was to evaluate the single dose toxicity of Yukmijihwangtanggamibang (YMJHTGMB), a polyherbal formula have been traditionally used as prevention or treatment agent for various lung diseases including chronic obstructive pulmonary disease (COPD), in male and female mice. Aqueous extracts of YMJHTGMB (Yield = 16.33%) wasadministered to female and male ICR mice as an oral dose of 2,000, 1,000 and 500 mg/kg (body weight) according to the recommendation of Korea Food and Drug Administration (KFDA) Guidelines. Animals were monitored for the mortality and changes in body weight, clinical signs and gross observation during 14 days after dosing, upon necropsy; organ weight and histopathology of 12 principle organs were examined. As results, we could not find any mortality, clinical signs, and changesin the body and organ weight except for soft feces restricted to YMJHTGMB 2,000 mg/kg treated two male mice (2/5; 40%) at 1 day after administration. In addition, no YMJHTGMB-treatment related abnormal gross findings and changes in histopathology of principle organs were detected except for some sporadic accidental findings. The results obtained in this study suggest that the 50% lethal dose and approximate lethal dose of YMJHTGMB aqueous extracts in both female and male mice were considered as over 2,000 mg/kg, the limited highest dosage recommended by KFDA Guidelines.
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참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Pauwels, R.A. / 2001 / Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary / Am. J. Respir. Crit. Care Med 163 : 1256 ~ 1276
2. [학술지(정기간행물)] - National Collaborating Centre for Chronic Conditions.Chronic obstructive pulmonary disease / 2004 / National clinical guideline on management of chronic obstructive pulmonary disease in adults in primary and secondary care / Thorax 59 : 1 ~ 232
3. [학술지(정기간행물)] - 박명재 / 2008 / 우리나라 일차 진료의사의 만성폐쇄성폐질환(COPD) 진료실태조사 / Tuberculosis and Respiratory Diseases 64 (2) : 109 ~ 124
4. [학술지(정기간행물)] - Chan, W.Y. / 1995 / Adverse effect of Tripterygium wilfordii extract on mouse embryonic development / Contraception 51 : 65 ~ 71
5. [학술지(정기간행물)] - Tanira, M.O. / 1996 / Toxicological effects of Teucrium stocksianum after acute and chronic administration in rats / J. Pharm. Pharmacol 48 : 1098 ~ 1102
2. [학술지(정기간행물)] - National Collaborating Centre for Chronic Conditions.Chronic obstructive pulmonary disease / 2004 / National clinical guideline on management of chronic obstructive pulmonary disease in adults in primary and secondary care / Thorax 59 : 1 ~ 232
3. [학술지(정기간행물)] - 박명재 / 2008 / 우리나라 일차 진료의사의 만성폐쇄성폐질환(COPD) 진료실태조사 / Tuberculosis and Respiratory Diseases 64 (2) : 109 ~ 124
4. [학술지(정기간행물)] - Chan, W.Y. / 1995 / Adverse effect of Tripterygium wilfordii extract on mouse embryonic development / Contraception 51 : 65 ~ 71
5. [학술지(정기간행물)] - Tanira, M.O. / 1996 / Toxicological effects of Teucrium stocksianum after acute and chronic administration in rats / J. Pharm. Pharmacol 48 : 1098 ~ 1102
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