지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
The object of this study was to observe the effects of Scutellariae Radix (SR) aqueous extracts on lipopolysaccharide (LPS)-induced rat acute lung injury. Five different dosages of SR extracts were orally administered once a day for 28 days before LPS treatments, and then 5 hours after lipopolysaccharide treatment, all rats were sacrificed. 8 groups, each of 16 rats per group were used in the present study. Changes on the body weights, lung weights, pulmonary transcapillary albumin transit, arterial gas parameters (pH, PaO₂ and PaCO₂) bronchoalveolar lavage fluid (BALF) protein, lactate dehydrogenase (LDH) and proinflammatory cytokines tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) contents, total cell numbers, neutrophil and alveolar macrophage ratios, lung malondialdehyde (MDA), myeloperoxidase (MPO), proinflammatory cytokine TNF-α and IL-1β contents were observed with histopathology of the lung, changes on luminal surface of alveolus (LSA), thickness of alveolar septum, number of polymorphonuclear neutrophils (PMNs). The results were compared with a potent antioxidant α-lipoic acid, 60 ㎎/㎏, in which the effects on LPS-induced acute lung injury were already confirmed. The results obtained in this study suggest that over 125 ㎎/㎏ of SR extracts showed favorable effects on the LPS-induced acute lung injury, and 250 ㎎/㎏ of SR extracts resembling acute respiratory distress syndrome mediated by their antioxidant and anti-inflammatory effects and .as similar to α-lipoic acid in the present study. Therefore, it is expected that SR will be showed favorable effects on the acute respiratory distress syndrome.
목차
서론
재료 및 방법
결과
고찰
결론
참고문헌
참고문헌 (42)
참고문헌 신청
1. [단행본] - 류종훈 / 2006 / 한방약리학 / 신일상사 : 186 ~ 191
2. [학술지(정기간행물)] - Gabrielska, J. / 1997 / Antioxidant activity of flavones from Scutellaria baicalensis in lecithin liposomes / Z Naturforsch [C] 52 : 817 ~ 823
3. [학술지(정기간행물)] - Wang, J.Y. / 2006 / Effects of Scutellaria baicalensis Georgi on macrophage-hepatocyte interaction through cytokines related to growth control of murine hepatocytes / Exp Biol Med (Maywood) 231 : 444 ~ 455
4. [학술지(정기간행물)] - Chung, H.L. / 2007 / Effect of Scutellariae Radix extract on experimental dextran-sulfate sodium-induced colitis in rats / World J Gastroenterol 13 : 5605 ~ 5611
5. [단행본] - Kasper Braunwald / 2006 / Harrison's 내과학 / MIP : 1737 ~ 1740
2. [학술지(정기간행물)] - Gabrielska, J. / 1997 / Antioxidant activity of flavones from Scutellaria baicalensis in lecithin liposomes / Z Naturforsch [C] 52 : 817 ~ 823
3. [학술지(정기간행물)] - Wang, J.Y. / 2006 / Effects of Scutellaria baicalensis Georgi on macrophage-hepatocyte interaction through cytokines related to growth control of murine hepatocytes / Exp Biol Med (Maywood) 231 : 444 ~ 455
4. [학술지(정기간행물)] - Chung, H.L. / 2007 / Effect of Scutellariae Radix extract on experimental dextran-sulfate sodium-induced colitis in rats / World J Gastroenterol 13 : 5605 ~ 5611
5. [단행본] - Kasper Braunwald / 2006 / Harrison's 내과학 / MIP : 1737 ~ 1740
이 논문의 저자 정보
최근 본 자료
댓글(0)
0