지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Nardostachyts chinensis (N. chinensis) belonging to the family Valerianaceae has been used to elicit stomachic and sedative effects. The MAPKs are serine/threonine kinases involved in the regulation of various cellular responses, such as cell proliferation, differentiation and apoptosis. The PKC also plays a key role in regulating the response of hematopoietic cells to both physiological and pathological inducers of proliferation and differentiation. This study investigated the signaling pathways on the U937 cell differentiation induced by N. chinensis. N. chinensis induced the differentiation of U937 cells, as shown by increased of differentiation surface antigen CD11b. Activation of ERK increased time-dependently in differentiation of U937 cells induced by N. chinensis, but activations of JNK and p38 were unaffected. Inhibitor of ERK (PD98059) significantly reduced CD11b expression induced by N. chinensis in U937 cells. In addition, N. chinensis increased protein level of PKC βI and PKC βII isoforms, but the protein level of PKC α and PKC γwas constant. PKC inhibitors (GF 109203X and H-7) inhibited U937 cell differentiation and the ERK activation induced by N. chinensis. These results indicated that PKC and ERK may be involved in U937 cell differentiation induced by N. chinensis.
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참고문헌 (46)
참고문헌 신청
1. [학술지(정기간행물)] - Mayer, R.J / 1994 / Intensive post-remission chemotherapy in adult with acute myeloid leukemia / Cancer and Leukemia Group B. N. Engl. J. Med 331 : 896 ~ 903
2. [단행본] - Hoffman, R / 2000 / Basic principles and practice / Churchill Livingstone : 1577 ~
3. [단행본] - / 2000 / Pharmacopoeia of the People's Republic of China, Vol. I / Chemical Industry Press : 65 ~
4. [학술지(정기간행물)] - Sang Hak Yoon / 2006 / Induction of human promyelocytic leukemia (HL-60) cell differentiation via a PKC/ERK pathway by the water extract of Nardostachys chinensis / 동의생리병리학회지 20 (5) : 1315 ~ 1320
5. [학술지(정기간행물)] - Cross, T.G / 2005 / Serine/threonine protein kinases and apoptosis / Exp. Cell Res 256 : 34 ~ 41
2. [단행본] - Hoffman, R / 2000 / Basic principles and practice / Churchill Livingstone : 1577 ~
3. [단행본] - / 2000 / Pharmacopoeia of the People's Republic of China, Vol. I / Chemical Industry Press : 65 ~
4. [학술지(정기간행물)] - Sang Hak Yoon / 2006 / Induction of human promyelocytic leukemia (HL-60) cell differentiation via a PKC/ERK pathway by the water extract of Nardostachys chinensis / 동의생리병리학회지 20 (5) : 1315 ~ 1320
5. [학술지(정기간행물)] - Cross, T.G / 2005 / Serine/threonine protein kinases and apoptosis / Exp. Cell Res 256 : 34 ~ 41
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