지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Galgeun-tang (GGT) has been a great source for treating cold diseases in the folk medicine recipe. Carbon tetrachloride (CCl4) is one type of hepatotoxin that can eventually cause liver injury. During the experiment, we first studied the protective effects of GGT against CC4-induced hepatotoxicity. GGT was pretreated for 3 h, and 1% CCl4 was added to mouse primary liver cells. After 4 h, ROS generation and expression of antioxidant enzymes (catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx)) were analyzed by FACS and real time PCR. Also, the activities of ALT and LDH were measured using cultured medium. The hepatic levels of TNF-alpha and iNOS, which are related to inflammation and stress response gene, HSP72 and HO-1 were analyzed by PCR or real time PCR. Liver tissues were analyzed by HE stain. From the observation, we discovered that GGT treatment protects CCl4-induced hepatotoxicity, and that GGT pretreatment decreases ROS generation, TNF-alpha and iNOS expression. However, gene expression of CAT, SOD, GPx, HSP72 and HO-1 were increased by GGT. These results lead to the conclusion that GGT has protective effects against CCl4-induced hepatotoxicity.
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고찰 및 결론
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참고문헌 (21)
참고문헌 신청
1. [학술지(정기간행물)] - Chang, Q. / 2008 / Simultaneous determination of ten active components in traditional Chinese medicinal products containing both Gegen (Pueraria lobata) and Danshen (Salvia miltiorrhiza) by high-performance liquid chromatography / Phytochem. Anal 19 : 368 ~ 375
2. [학술지(정기간행물)] - Jeong Mi Shin / 2008 / Free radical scavenging activity and kinetic behavior of the Galgeuntangwater extract / Oriental Pharmacy and Experimental Medicine 8 (1) : 32 ~ 38
3. [학술지(정기간행물)] - Wang, Y. / 2009 / Simultaneous determination of puerarin, daidzein, baicalin, wogonoside and liquiritin of GegenQinlian decoction in rat plasma by ultra-performance liquid chromatography–mass spectrometry / J. Chromatogra. B 877 : 1820 ~ 1826
4. [단행본] - 박영순 / 2002 / 한방의 약리해설 / 아카데미서적 : 196 ~ 202
5. [학술지(정기간행물)] - Lyu, S.A. / 2006 / Seungma-galgeun-tang attenuates proinflammatory activities through the inhibition of NF-kappa B signal pathway in the BV-2 microglial cells / JOURNAL OF ETHNOPHARMACOLOGY 107 (1) : 59 ~ 66
2. [학술지(정기간행물)] - Jeong Mi Shin / 2008 / Free radical scavenging activity and kinetic behavior of the Galgeuntangwater extract / Oriental Pharmacy and Experimental Medicine 8 (1) : 32 ~ 38
3. [학술지(정기간행물)] - Wang, Y. / 2009 / Simultaneous determination of puerarin, daidzein, baicalin, wogonoside and liquiritin of GegenQinlian decoction in rat plasma by ultra-performance liquid chromatography–mass spectrometry / J. Chromatogra. B 877 : 1820 ~ 1826
4. [단행본] - 박영순 / 2002 / 한방의 약리해설 / 아카데미서적 : 196 ~ 202
5. [학술지(정기간행물)] - Lyu, S.A. / 2006 / Seungma-galgeun-tang attenuates proinflammatory activities through the inhibition of NF-kappa B signal pathway in the BV-2 microglial cells / JOURNAL OF ETHNOPHARMACOLOGY 107 (1) : 59 ~ 66
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