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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.2
- 수록면
- 35 - 44 (10page)
- DOI
- 10.15188/kjopp.2014.02.28.1.35
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초록· 키워드
오류제보하기
This study was performed to investigate the anti-photoaging effects of Persimmon leaf tea(PLT) in hairless mice(SKH-1) exposed to UVB radiation. The animals were divided into non-treated group (normal, N) and UV-radiated groups. UV-radiated groups were divided into only UV-radiated group(control, C) and UV-radiated and PLT treated experimental groups[first extraction treated group(PLT-I), second extraction treated groupe(PLT-II), and third extraction treated group(PLT-III)]. Three PLT treated experimental groups of mice were treated with both oral administration(300mg/Kg B.W./day) and topical application (100 ul of 2% conc./mouse/day) for 4 weeks. Anti-photoaging effects of Persimmon leaf were evaluated by MTT assay, anti oxidative reaction, MMP immunohistochemistry, gelatin zymography assay and RT-PCR observations. Treatment with Persimmon leaf tea(PLT)-I, and -III groups decreased immunohistochemical density of matrix metalloproteinases(MMP)-3 and -9 related to degradation of extracellular matrix in skin. Especially, immunohistochemical density of MMP-2 decreased in PLT-I, -II and ?III groups in skin. On the effects of antioxidant function on the treatment with Persimmon leaf tea(PLT), treatment of HaCaT cells with extracts of PLT-I and PLT-II had also significantly reduced intracellular ROS produced by UVB irradiation in a dose dependent manner(PLT-I, p<0.05, p<0.01, p<0.001; PLT-II, p<0.01, p<0.001). Gelatin zymography assay revealed that PLT-II and PLT-III (200 ug/ml) had inhibitory effect on MMP-9 expression in UVB-radiated HaCaT cells. Western blot analysis revealed that PLT-1, -II and -III groups down-regulates the expression of inflammatory associated genes(IL-1β) and PLT-1 and -II groups down-regulates the expression of TNF-α in a dose dependent manner. Our study suggests that Persimmon leaf tea(PLT) extracts participates in inhibitory effects on the morphological and molecular experiments related to photoaging skin on UVB irradiated hairless mice.
목차
서론
재료 및 방법
결과
고찰
결론
참고문헌
참고문헌 (56)
참고문헌 신청
1. [학술지(정기간행물)] - Meinhard, W. / 2001 / Solar UV irradiation and dermal photoaging / J Photochem and Photobiology 63 : 41 ~ 51
2. [학술지(정기간행물)] - Gilchrest, B.A. / 1989 / Skin aging and photoaging: an overview / J Am Acad Dermatol 989 (21) : 610 ~ 613
3. [학술지(정기간행물)] - Griffiths, C.E.M. / 1992 / The clinical identification and quantification of photodamage / Br J Dermatol 127 (41) : 37 ~ 42
4. [학술지(정기간행물)] - Lavker, R.M. / 1979 / Structural alterations in exposed and unexposed aged skin / J Invest Dermatol 73 : 59 ~ 66
5. [학술지(정기간행물)] - Kligman, A.M. / 1986 / Topical tretinoin for photodamaged skin / J Am Acad Dermatol 15 : 836 ~ 859
2. [학술지(정기간행물)] - Gilchrest, B.A. / 1989 / Skin aging and photoaging: an overview / J Am Acad Dermatol 989 (21) : 610 ~ 613
3. [학술지(정기간행물)] - Griffiths, C.E.M. / 1992 / The clinical identification and quantification of photodamage / Br J Dermatol 127 (41) : 37 ~ 42
4. [학술지(정기간행물)] - Lavker, R.M. / 1979 / Structural alterations in exposed and unexposed aged skin / J Invest Dermatol 73 : 59 ~ 66
5. [학술지(정기간행물)] - Kligman, A.M. / 1986 / Topical tretinoin for photodamaged skin / J Am Acad Dermatol 15 : 836 ~ 859
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