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Kaempferol, a component of Polygonati rhizoma, is one of the herbal flavonoids, which is used in therapeutic agent for anti-hypercholesterol, anti-hypertension and anti-diabetes. And it is also known to be effective in anti-cancer therapy for breast, prostate and other type of cancers. However, the anti-cancer therapeutic mechanisms are pooly understood. To address molecular mechanism underlying kaempferol-induced anti-cancer effects, we determined the effect of kaempferol on cell growth of the lung cancer cell lines, A549, H1299 and H460. From the FACS analysis, measurement of caspase activity, DAPI and tryptophan blue staining, and DNA fragmentation assay, we found that kaempferol induces apoptosis and H460 cells are most sensitive among the tested cell lines. In addition, we performed microarray to identify the genome-wide expression profiling regulated by kaempferol. Lots of cell cycle-related genes were under-expressed, whereas the genes related to TGF-beta/SMAD pathway were over-expressed in kaempferol-treated H460 cells. Additionally, kaempferol also increased expression levels of apoptosis related genes such as death receptors, FAS, TRAIL-R and TNF-R, and casepase-8 and caspase-10. Overall, our results suggest that kaempferol promotes anti-lung cancer therapeutic effects by inducing G1 arrest and apoptosis through TGF-beta/SMAD pathway and death receptors/caspase pathway, respectively.
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참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Preetha Anand / 2008 / Cancer is a Preventable Disease that Requires Major Lifestyle Changes / Pharmaceutical Research 25 (9) : 2097 ~ 2116
2. [학술지(정기간행물)] - Cho, G.J / 2002 / Current therapy of lung cancer / Korean Journal of Medicine 62 (2) : 600 ~ 607
3. [학술지(정기간행물)] - Seo, W.G. / 1999 / Effects of Trichosanthes kirilowii Maxim and Scutellaria baicalensis Georgi on IL-1β-induced GnT-Ⅲ and Ⅴ in Melanoma B-16 / J. of Kor. Oriental Oncology 5 (1) : 103 ~ 118
4. [학술지(정기간행물)] - Lee, H. / 2010 / Methyl Gallate Exhibits Potent Antitumor Activities by Inhibiting Tumor Infiltration of CD4(+)CD25(+) Regulatory T Cells / JOURNAL OF IMMUNOLOGY 185 (11) : 6698 ~ 6705
5. [학술지(정기간행물)] - Lee, H.J. / 2006 / An oriental herbal cocktail, ka-mi-kae-kyuk-tang, exerts anti-cancer activities by targeting angiogenesis, apoptosis and metastasis / CARCINOGENESIS 27 : 2455 ~ 2463
2. [학술지(정기간행물)] - Cho, G.J / 2002 / Current therapy of lung cancer / Korean Journal of Medicine 62 (2) : 600 ~ 607
3. [학술지(정기간행물)] - Seo, W.G. / 1999 / Effects of Trichosanthes kirilowii Maxim and Scutellaria baicalensis Georgi on IL-1β-induced GnT-Ⅲ and Ⅴ in Melanoma B-16 / J. of Kor. Oriental Oncology 5 (1) : 103 ~ 118
4. [학술지(정기간행물)] - Lee, H. / 2010 / Methyl Gallate Exhibits Potent Antitumor Activities by Inhibiting Tumor Infiltration of CD4(+)CD25(+) Regulatory T Cells / JOURNAL OF IMMUNOLOGY 185 (11) : 6698 ~ 6705
5. [학술지(정기간행물)] - Lee, H.J. / 2006 / An oriental herbal cocktail, ka-mi-kae-kyuk-tang, exerts anti-cancer activities by targeting angiogenesis, apoptosis and metastasis / CARCINOGENESIS 27 : 2455 ~ 2463
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간암 세포주에서 黃精의 주요 성분인 Kaempferol의 성장 억제 효과
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UCI(KEPA) : I410-ECN-0101-2015-510-001213874