지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Oxidative stress has been implicated in cutaneous damage in various inflammatory skin diseases, including atopic dermatitis. The present study was undertaken to investigate the antioxidative and anti-inflammatory activities of the extract of Duchesnea chrysantha (DCE). DEC was prepared by extracting with 80% ethanol. Total flavonoids and polyphenols were measured by a colorimetric assay. The free radical scavenging activity of the extract was analyzed by the DPPH (1,1-diphenyl-2-picryl hydrazyl), ABTS (2,2’-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) and Griess reagent assay. An oxidative product of nitric oxide (NO), was measured in the culture medium by the Griess reaction. The level of prostaglandin E2 (PGE2) was measured by enzyme-linked immunosorbent assay. The expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were measured by Western blot analysis. Total flavonoid and polyphenol contents of DCE were included 24.73±0.45 and 178.77±2.65, respectively. DCE significantly increased electron donating ability (DPPH), nitrite scavenging (NO) and ABTS reducing activity in dose dependant. We investigated the anti-inflammatory effects of DCE on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. DCE significantly suppressed NO and prdstaglandin E2 (PGE2) in dose dependant. Furthermore, the levels of iNOS and COX-2 protein expressions were markedly suppressed by the treatment with DCE in a dose dependent manner. These results suggest that DEC may has value as natural product with its high quality functional components, antioxidative and anti-inflammatory activities.
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참고문헌 (28)
참고문헌 신청
1. [학술지(정기간행물)] - Geronikaki, A. A / 2006 / Antioxidants and inflammatory disease: synthetic and natural antioxidants with anti-inflammatory activity / Comb Chem High Throughput Screen 9 : 425 ~ 442
2. [학술지(정기간행물)] - Kondo, T / 2009 / Roles of oxidative stress and redox regulation in atherosclerosis / J Atheroscler Thromb 6 : 532 ~ 538
3. [학술지(정기간행물)] - Kastle, M / 2011 / Protein oxidative modification in the aging organism and the role of the ubiquitin proteasomal system / Curr Pharm Des 17 : 4007 ~ 4022
4. [학술지(정기간행물)] - Cho, H. R / 2011 / Glutathione S-transferase M1 (GSTM1) polymorphism is associated with atopic dermatitis susceptibility in a Korean population / Int J Immunogenet 38 : 145 ~ 150
5. [학술지(정기간행물)] - Wakamatsu, T. H / 2010 / Evaluation of lipid oxidative stress status and inflammation in atopic ocular surface disease / Mol Vis 16 : 2465 ~ 2475
2. [학술지(정기간행물)] - Kondo, T / 2009 / Roles of oxidative stress and redox regulation in atherosclerosis / J Atheroscler Thromb 6 : 532 ~ 538
3. [학술지(정기간행물)] - Kastle, M / 2011 / Protein oxidative modification in the aging organism and the role of the ubiquitin proteasomal system / Curr Pharm Des 17 : 4007 ~ 4022
4. [학술지(정기간행물)] - Cho, H. R / 2011 / Glutathione S-transferase M1 (GSTM1) polymorphism is associated with atopic dermatitis susceptibility in a Korean population / Int J Immunogenet 38 : 145 ~ 150
5. [학술지(정기간행물)] - Wakamatsu, T. H / 2010 / Evaluation of lipid oxidative stress status and inflammation in atopic ocular surface disease / Mol Vis 16 : 2465 ~ 2475
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